基于互联网的多发性硬化症患者运动与身体活动促进：一项随机对照试验。
Internet-based exercise and physical activity promotion for persons with multiple sclerosis: a randomized controlled trial.
作者信息
Hartung Verena, Tallner Alexander, Flachenecker Peter, Mäurer Mathias, Streber René, Wanner Philipp, Rashid Asarnusch, Shammas Layal, Hois Gottfried, Dettmers Christian, Roick Holger, Stefanou Alexander, Tumani Hayrettin, Weber Susanne, Pfeifer Klaus
机构信息
Department of Sport Science and Sport, Friedrich-Alexander-Universität Erlangen-Nürnberg, Gebbertstraße 123b, 91058, Erlangen, Germany.
ZTM Bad Kissingen GmbH, Münchner Straße 5, 97688, Bad Kissingen, Germany.
出版信息
BMC Sports Sci Med Rehabil. 2025 Apr 23;17(1):90. doi: 10.1186/s13102-025-01146-x.
BACKGROUND
We evaluated the effects of a 12-week internet-based exercise and physical activity promotion program for persons with multiple sclerosis.
METHODS
We performed a multicenter, randomized, waitlist-controlled study. The intervention group (IG) received the 12-week program, followed by 12 weeks with usual care. The control group (CG) received usual care only. The main components of the 12-week program were: (1) a tailored home-based exercise prescription, (2) e-learning resources, (3) telephone and video meetings with an exercise therapist, (4) the provision of a consumer-based PA monitor. Measurements were taken at baseline, postintervention, and after 24 weeks. The primary outcome was device-measured steps/day. Other outcomes were device-measured moderate-to-vigorous physical activity, subjectively measured leisure-time and transportation physical activity and sport/exercise, physical activity-related health competence, walking ability, quality of life, fatigue, depression, and PA-related self-concordance. We compared changes from baseline to postintervention between groups and analyzed changes in the IG during the follow-up.
RESULTS
Analysis of 56 persons with multiple sclerosis (IG: n = 29, CG: n = 27, age: 45.6 ± 10.9) revealed no significant intervention effect on steps/day. However, significant improvements were observed in moderate-to-vigorous physical activity, sport/exercise, control competence, fatigue, and quality of life (physical). During the follow-up, sport/exercise and quality of life decreased significantly. Leisure-time and transportation physical activity increased significantly.
CONCLUSIONS
Our study provides first evidence that the developed program can increase control competence, aspects of physical activity and health in persons with multiple sclerosis. A trial with a larger sample is recommended to confirm our results and examine intervention mechanisms.
TRIAL REGISTRATION
Registry: Clinicaltrials.gov; registration number: NCT04367389; date of registration: 2020-04-21 (retrospectively registered).
背景
我们评估了一项为期12周的基于互联网的运动和身体活动促进计划对多发性硬化症患者的影响。
方法
我们进行了一项多中心、随机、等待名单对照研究。干预组（IG）接受为期12周的计划，随后是12周的常规护理。对照组（CG）仅接受常规护理。为期12周的计划的主要组成部分包括：（1）量身定制的居家运动处方，（2）电子学习资源，（3）与运动治疗师的电话和视频会议，（4）提供基于消费者的身体活动监测器。在基线、干预后和24周后进行测量。主要结局是通过设备测量的每日步数。其他结局包括通过设备测量的中度至剧烈身体活动、主观测量的休闲时间和交通身体活动以及运动/锻炼、与身体活动相关的健康能力、步行能力、生活质量、疲劳、抑郁以及与身体活动相关的自我和谐度。我们比较了两组从基线到干预后的变化，并分析了随访期间IG的变化。
结果
对56例多发性硬化症患者（IG：n = 29，CG：n = 27，年龄：45.6±10.9）的分析显示，该干预对每日步数没有显著影响。然而，在中度至剧烈身体活动、运动/锻炼、控制能力、疲劳和生活质量（身体方面）方面观察到显著改善。在随访期间，运动/锻炼和生活质量显著下降。休闲时间和交通身体活动显著增加。
结论
我们的研究首次证明，所开发的计划可以提高多发性硬化症患者的控制能力、身体活动和健康方面。建议进行更大样本的试验以证实我们的结果并研究干预机制。
试验注册
注册机构：Clinicaltrials.gov；注册号：NCT04367389；注册日期：2020年4月21日（追溯注册）。
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