Department of Kinesiology and Nutrition, University of Illinois Chicago, 545 AHSB, 1919 W. Taylor St., Chicago, IL 60612, United States.
Department of Kinesiology and Nutrition, University of Illinois Chicago, 545 AHSB, 1919 W. Taylor St., Chicago, IL 60612, United States.
Mult Scler Relat Disord. 2023 Dec;80:105124. doi: 10.1016/j.msard.2023.105124. Epub 2023 Nov 9.
Persons with multiple sclerosis (MS) engage in less physical activity than the general population, and the disease manifestations and comorbidity conditions might further predispose them toward sedentary behavior (SB) among this population. We performed a systematic review with meta-analysis of studies that compared SB in persons with MS and non-MS controls, and examined factors that may moderate the difference in SB between the two groups.
We conducted a systematic search using PubMed, PsycINFO, Scopus, and CINAHL from inception up to August 2022, and identified studies that involved group comparison of SB outcomes between MS and non-MS controls. Effect sizes were calculated as standardized mean differences (SMDs) using Hedge's g. We generated a multilevel random-effects model for estimating an overall effect, and performed moderator analyses. Methodological quality was assessed using the Appraisal Tool for Cross-Sectional Studies (AXIS tool).
Eleven studies were included (1403 MS vs. 449 controls) and yielded 17 effects for meta-analysis. Results indicated an overall small, but significant effect (SMD [95% CI] = 0.27 [0.02, 0.53], p = 0.03) with significant heterogeneity (Q = 72.2, p < 0.01; I = 75.8%). There were larger effects when the MS sample had a higher proportion of females, or when SB was reported as percent sedentary time per day compared with other SB outcomes (p = 0.03 and 0.05, respectively). The included studies achieved fairly good quality (91.4%) using the AXIS tool.
The cumulative evidence supports that persons with MS engage in more SB than non-MS controls. Our findings may support the design of targeted behavioral change interventions for reducing SB and improving health and function in the MS population.
多发性硬化症（MS）患者的身体活动量低于一般人群，而且疾病表现和合并症可能使他们在这一人群中更容易出现久坐行为（SB）。我们对比较 MS 患者和非 MS 对照组 SB 的研究进行了系统回顾和荟萃分析，并研究了可能调节两组之间 SB 差异的因素。
我们使用 PubMed、PsycINFO、Scopus 和 CINAHL 进行了系统搜索，从开始到 2022 年 8 月，确定了涉及 MS 和非 MS 对照组 SB 结果组间比较的研究。使用 Hedge's g 计算效应大小作为标准化均数差（SMD）。我们生成了一个多水平随机效应模型来估计总体效应，并进行了调节分析。使用横断面研究评估工具（AXIS 工具）评估方法学质量。
纳入了 11 项研究（1403 例 MS 与 449 例对照），进行了 17 项荟萃分析。结果表明，总体上存在较小但显著的效应（SMD [95% CI] = 0.27 [0.02, 0.53]，p = 0.03），且存在显著的异质性（Q = 72.2，p < 0.01；I = 75.8%）。当 MS 样本中女性比例较高，或当 SB 报告为每天久坐时间的百分比时，与其他 SB 结果相比，效应更大（分别为 p = 0.03 和 0.05）。使用 AXIS 工具，纳入的研究质量相当高（91.4%）。
累积证据支持 MS 患者比非 MS 对照组更多地进行 SB。我们的研究结果可能支持设计针对 MS 人群的行为改变干预措施，以减少 SB 并改善健康和功能。
