Liu Kai, Lian Xiaogang, Wang Ting, Tao Zhu
School of Physical Education, Changzhi University, Changzhi, Shanxi, China.
Research Center for Sports Culture and Social Development, Changzhi University, Changzhi, Shanxi, China.
Am J Mens Health. 2025 Mar-Apr;19(2):15579883251336056. doi: 10.1177/15579883251336056. Epub 2025 Apr 24.
Physical activity is associated with stress urinary incontinence (SUI). The genetic causality of this association remains unclear. This study used the Mendelian randomization (MR) method to explore the potential causal relationship between physical activity and SUI risk using heavy do-it-yourself (DIY), light DIY, strenuous sports, walking for pleasure, and other exercises as proxies. We selected single nucleotide polymorphisms associated with physical activity from published genome-wide association studies (GWAS). Statistics of SUI come from the GWAS database. MR estimation was performed using the inverse variance weighting method, the MR-Egger method, and the weighted median method. Sensitivity analyses were performed using Cochran's test, MR-Egger intercept, MR-pleiotropy residuals, outlier methods, leave-one-out analysis, and funnel plots. The results showed that there was a causal relationship between heavy DIY and SUI ( = 0.9712, 95% confidence interval [0.951, 0.9918], = .006), while no significant causal relationship was found between other physical activities and SUI. These findings were robust across multiple sensitivity analyses. This MR study demonstrates the causal relationship between heavy DIY and SUI, helping doctors and researchers better recommend preventive and treatment measures to patients, while also providing specific directions for improving their lifestyle in men and women suffering from SUI.
身体活动与压力性尿失禁（SUI）相关。这种关联的遗传因果关系尚不清楚。本研究采用孟德尔随机化（MR）方法，以重度自己动手做（DIY）、轻度DIY、剧烈运动、休闲散步及其他运动为代表，探讨身体活动与SUI风险之间的潜在因果关系。我们从已发表的全基因组关联研究（GWAS）中选择与身体活动相关的单核苷酸多态性。SUI的统计数据来自GWAS数据库。采用逆方差加权法、MR-Egger法和加权中位数法进行MR估计。使用 Cochr an检验、MR-Egger截距、MR多效性残差、异常值法、留一法分析和漏斗图进行敏感性分析。结果显示，重度DIY与SUI之间存在因果关系（ = 0.9712，95%置信区间[0.951, 0.9918]， = 0.006），而其他身体活动与SUI之间未发现显著因果关系。这些发现在多项敏感性分析中均很稳健。这项MR研究证明了重度DIY与SUI之间的因果关系，有助于医生和研究人员更好地向患者推荐预防和治疗措施，同时也为改善患有SUI的男性和女性的生活方式提供了具体指导。
