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非人灵长类动物(猕猴和白唇狨)食用晚疫病马铃薯的致畸性研究。

Teratogenicity studies on late blighted potatoes in nonhuman primates (Macaca mulatta and Saguinus labiatus).

作者信息

Allen J R, Marlar R J, Chesney C F, Helgeson J P, Kelman A, Weckel G, Traisman E, White J W

出版信息

Teratology. 1977 Feb;15(1):17-23. doi: 10.1002/tera.1420150103.

DOI:10.1002/tera.1420150103
PMID:402704
Abstract

Female rhesus monkeys and marmosets were fed a diet containing blighted potatoes (Phytophthora infestans) at a level of 10g/kg per day for at least two weeks prior to breeding and six weeks following conception in order to gain additional information on the association of blighted potatoes and the development of anencephaly and spina bifida in primate species. There was an absence of either of these neural-tube defects in 32 rhesus and 14 marmoset infants whose mothers had received a blighted potato diet. In addition there were no cranial osseous defects. There were, however, two rhesus monkey infants with internal hydrocephalus whose mothers had consumed blighted potatoes.

摘要

在雌性恒河猴和狨猴繁殖前至少两周及受孕后六周,每天给它们喂食含枯萎马铃薯(致病疫霉)的食物,剂量为每千克10克,以便获取更多关于枯萎马铃薯与灵长类动物无脑儿和脊柱裂发育之间关联的信息。32只恒河猴和14只狨猴幼崽的母亲食用了枯萎马铃薯,但这些幼崽均未出现上述任何一种神经管缺陷。此外,也没有颅骨骨质缺陷。然而,有两只恒河猴幼崽出现了内部脑积水,它们的母亲食用了枯萎马铃薯。

相似文献

1
Teratogenicity studies on late blighted potatoes in nonhuman primates (Macaca mulatta and Saguinus labiatus).非人灵长类动物(猕猴和白唇狨)食用晚疫病马铃薯的致畸性研究。
Teratology. 1977 Feb;15(1):17-23. doi: 10.1002/tera.1420150103.
2
Blighted potatoes, blighted fetus?枯萎的土豆,枯萎的胎儿?
Can Med Assoc J. 1972 Dec 23;107(12):1160.
3
Potatoes and spina bifida.土豆与脊柱裂。
Proc R Soc Med. 1974 May;67(5):360-4. doi: 10.1177/003591577406700514.
4
Potatoes and birth defects: summary.土豆与出生缺陷:总结
Teratology. 1973 Dec;8(3):319-20. doi: 10.1002/tera.1420080313.
5
Failure to induce malformations in fetal rats by feeding blighted potatoes to their mothers.
Lancet. 1973 Feb 10;1(7798):329-30. doi: 10.1016/s0140-6736(73)91591-2.
6
Teratogenic potential of blighted potato concentrate in rabbits, hamsters, and miniature swine.枯萎马铃薯浓缩物对家兔、仓鼠和小型猪的致畸潜力。
Teratology. 1978 Aug;18(1):55-61. doi: 10.1002/tera.1420180109.
7
Anencephaly and spina bifida: possible association with potato blight.无脑儿和脊柱裂:可能与马铃薯晚疫病有关。
Med J Aust. 1972 Nov 18;2(21):1208. doi: 10.5694/j.1326-5377.1972.tb103803.x.
8
Anencephaly, spina bifida, and potato blight in the Edinburgh area.爱丁堡地区的无脑儿、脊柱裂和马铃薯晚疫病。
Lancet. 1973 Feb 3;1(7797):269. doi: 10.1016/s0140-6736(73)90115-3.
9
Questions concerning the possible association of potatoes and neural-tube defects, and an alternative hypothesis relating to maternal growth and development.关于土豆与神经管缺陷可能关联的问题,以及一个与母体生长发育相关的替代假说。
Teratology. 1973 Dec;8(3):325-31. doi: 10.1002/tera.1420080315.
10
Spina bifida, anencephaly, and potato blight.脊柱裂、无脑儿和马铃薯晚疫病。
Lancet. 1973 Feb 24;1(7800):426-7. doi: 10.1016/s0140-6736(73)90282-1.

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