枯萎马铃薯浓缩物对家兔、仓鼠和小型猪的致畸潜力。

Teratogenic potential of blighted potato concentrate in rabbits, hamsters, and miniature swine.

作者信息

Sharma R P, Willhite C C, Wu M T, Salunkhe D K

出版信息

Teratology. 1978 Aug;18(1):55-61. doi: 10.1002/tera.1420180109.

DOI:10.1002/tera.1420180109

Abstract

Freeze-dried preparations of potatoes infected with phytophthora infestans or Alternaria solani were fed to pregnant hamsters, rabbits, and miniature swine. No evidence was observed that these diets or the extracts of respective blights were capable of producing teratologic effects in hamsters. Lesions of neurulation and anencephaly were noticed in rabbits and swine, respectively. The need for further pharmacological and toxicological evaluation in sensitive species is emphasized.

摘要

将感染致病疫霉或链格孢菌的马铃薯冻干制剂喂给怀孕的仓鼠、兔子和小型猪。未观察到有证据表明这些饮食或各自疫病的提取物能够在仓鼠中产生致畸作用。分别在兔子和猪中发现了神经胚形成病变和无脑畸形。强调需要对敏感物种进行进一步的药理学和毒理学评估。