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大腿前内侧罕见的轴外脊索瘤：病例报告

Rare Extra-Axial Chordoma of the Anteromedial Thigh: A Case Report.

作者信息

Tibbo Meagan E, Mysore Nishad, Jose Jean, Rosenberg Andrew E, Temple H Thomas

机构信息

Department of Orthopedic Surgery Mayo Clinic Phoenix Arizona USA.

Division of Musculoskeletal Radiology, Department of Radiology University of Miami Miami Florida USA.

出版信息

Clin Case Rep. 2025 Apr 22;13(4):e70341. doi: 10.1002/ccr3.70341. eCollection 2025 Apr.

DOI:10.1002/ccr3.70341
PMID:40270777
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12014511/
Abstract

Chordomas are rare notochordal malignancies typically occurring in the axial skeleton. Less than 100 extra-axial chordomas have been reported. We describe a unique chordoma of the anteromedial thigh. The clinical presentation of extra-axial chordomas is highly variable; thus, recognizing this entity in the differential diagnoses of extra-axial bone/soft tissue tumors is important.

摘要

脊索瘤是罕见的脊索恶性肿瘤，通常发生于中轴骨骼。据报道，轴外脊索瘤少于100例。我们描述了一例大腿前内侧的独特脊索瘤。轴外脊索瘤的临床表现高度多变；因此，在轴外骨/软组织肿瘤的鉴别诊断中识别这一实体很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4da/12014511/431198d2317d/CCR3-13-e70341-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4da/12014511/36257d95236f/CCR3-13-e70341-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4da/12014511/d4d96e9c9ac2/CCR3-13-e70341-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4da/12014511/2626257622f6/CCR3-13-e70341-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4da/12014511/9496f3665166/CCR3-13-e70341-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4da/12014511/431198d2317d/CCR3-13-e70341-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4da/12014511/36257d95236f/CCR3-13-e70341-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4da/12014511/d4d96e9c9ac2/CCR3-13-e70341-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4da/12014511/2626257622f6/CCR3-13-e70341-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4da/12014511/9496f3665166/CCR3-13-e70341-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4da/12014511/431198d2317d/CCR3-13-e70341-g004.jpg

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本文引用的文献

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SMARCB1/INI1 loss in skull base conventional chordomas: a clinicopathological and molecular analysis.颅底传统型脊索瘤中SMARCB1/INI1缺失：一项临床病理与分子分析
Front Oncol. 2023 Jun 30;13:1160764. doi: 10.3389/fonc.2023.1160764. eCollection 2023.
2
Recurrent loss of chromosome 22 and SMARCB1 deletion in extra-axial chordoma: A clinicopathological and molecular analysis.颅外脊索瘤中 22 号染色体的反复丢失和 SMARCB1 缺失：临床病理和分子分析。
Genes Chromosomes Cancer. 2021 Dec;60(12):796-807. doi: 10.1002/gcc.22992. Epub 2021 Aug 26.
3
Extra-axial chordoma of the thumb: Report of a rare case with clinicopathologic and molecular analysis.
拇指的轴外脊索瘤：1例罕见病例的临床病理及分子分析报告
Pathol Res Pract. 2021 Sep;225:153564. doi: 10.1016/j.prp.2021.153564. Epub 2021 Jul 22.
4
Recent advances in understanding and managing chordomas: an update.脊索瘤理解与管理的最新进展：最新情况
F1000Res. 2020 Jul 16;9. doi: 10.12688/f1000research.22440.1. eCollection 2020.
5
Intra-articular extra-axial chordoma of the wrist: a case report with review of the current literature.腕关节关节内椎管外脊索瘤：一例病例报告并文献复习。
Skeletal Radiol. 2019 Dec;48(12):2015-2020. doi: 10.1007/s00256-019-03228-7. Epub 2019 May 18.
6
Clinicopathological and Prognostic Characteristics in Extra-Axial Chordomas: An Integrative Analysis of 86 Cases and Comparison With Axial Chordomas.颅外脊索瘤的临床病理和预后特征：86 例综合分析，并与轴性脊索瘤比较。
Neurosurgery. 2019 Sep 1;85(3):E527-E542. doi: 10.1093/neuros/nyz073.
7
Extra-axial chordoma: a clinicopathologic analysis of six cases.颅外脊索瘤：六例临床病理分析。
Virchows Arch. 2018 Jun;472(6):1015-1020. doi: 10.1007/s00428-018-2334-0. Epub 2018 Mar 20.
8
Extra-Axial Chordoma of the Hand.手部轴外脊索瘤
J Hand Surg Am. 2017 Nov;42(11):933.e1-933.e5. doi: 10.1016/j.jhsa.2017.05.033. Epub 2017 Jul 12.
9
Extra-axial chordomas.轴外脊索瘤
Ann R Coll Surg Engl. 2016 May;98(5):324-8. doi: 10.1308/rcsann.2016.0138.
10
Primary, large extra-axial chordoma in proximal tibia: a rare case report with literature review and diagnostic implications.原发性近端胫骨大型轴外脊索瘤：1例罕见病例报告并文献复习及诊断意义
APMIS. 2016 Mar;124(3):238-42. doi: 10.1111/apm.12468. Epub 2015 Nov 2.