Connors Scott W, Aoun Salah G, Shi Chen, Peinado-Reyes Valery, Hall Kristen, Bagley Carlos A
Department of Neurological Surgery, University of Texas Southwestern School of Medicine, Dallas, TX, USA.
UT Southwestern Spine Center, University of Texas Southwestern School of Medicine, Dallas, TX, USA.
F1000Res. 2020 Jul 16;9. doi: 10.12688/f1000research.22440.1. eCollection 2020.
Chordomas are rare and difficult-to-treat tumors arising from the embryonic notochord. While surgery is the mainstay of treatment, and despite new techniques aimed at maximizing total tumoral resection, recurrence remains high and the probability of disease-free survival low. New breakthroughs in genetics, targeted molecular therapy, and heavy-particle beam therapy offer some promise as adjuvant treatments in addition to surgical resection. A multidisciplinary approach encompassing genetics, immunotherapy, radiation therapy, and surgery, at a facility experienced in the management of this complex disease, offers the best chance of survival and quality of life to patients while limiting the intrinsic morbidity of these treatments.
脊索瘤是一种罕见且难以治疗的肿瘤，起源于胚胎脊索。虽然手术是主要治疗方法，尽管有旨在最大限度地实现肿瘤全切的新技术，但复发率仍然很高，无病生存率很低。遗传学、靶向分子治疗和重粒子束治疗方面的新突破为除手术切除外的辅助治疗带来了一些希望。在一家有处理这种复杂疾病经验的机构，采用涵盖遗传学、免疫治疗、放射治疗和手术的多学科方法，可为患者提供最佳的生存机会和生活质量，同时限制这些治疗的固有发病率。
