McCredie R M, McKenzie W B, McGill D A
Br J Clin Pharmacol. 1985;20 Suppl 1(Suppl 1):163S-168S. doi: 10.1111/j.1365-2125.1985.tb05160.x.
The haemodynamic effects of oral nicardipine at two different doses were assessed in fifteen patients at rest following diagnostic cardiac catheterisation. Six patients received four doses of 20 mg nicardipine hydrochloride orally every 8 h, and nine patients received four doses of 30 mg orally every 8 h. No side effects were encountered with either dose. At both dose levels, there was a significant fall in systemic vascular resistance, significant increases in heart rate and cardiac output, and no change in stroke volume index. No changes were seen in pulmonary vascular haemodynamics, and there were no significant changes in mean arterial pressure. Plasma levels of nicardipine reached a peak within 1 h. In parallel with the haemodynamic effects, the plasma concentrations achieved after the third and fourth doses were higher than after the first dose. These haemodynamic changes are consistent with a vasodilator effect, which produces a decrease in peripheral vascular resistance. It would appear that the 30 mg dose has a more potent vasodilator action than the 20 mg dose and, in the patients studied, this larger dose was not associated with any side effects.
在15例诊断性心导管检查后静息状态的患者中，评估了两种不同剂量口服尼卡地平的血流动力学效应。6例患者每8小时口服4剂20mg盐酸尼卡地平，9例患者每8小时口服4剂30mg。两种剂量均未出现副作用。在两个剂量水平上，全身血管阻力均显著下降，心率和心输出量显著增加，每搏量指数无变化。肺血管血流动力学未见变化，平均动脉压无显著变化。尼卡地平血浆水平在1小时内达到峰值。与血流动力学效应一致，第三剂和第四剂后的血浆浓度高于第一剂后。这些血流动力学变化与血管扩张剂效应一致，血管扩张剂效应导致外周血管阻力降低。似乎30mg剂量比20mg剂量具有更强的血管扩张作用，并且在研究的患者中，这种较大剂量未伴有任何副作用。
