Thyss A, Schneider M, Caldani C, Viot M, Bourry J
Br J Cancer. 1985 Aug;52(2):183-7. doi: 10.1038/bjc.1985.176.
Electrophoretic isoenzyme separation provides much more precise information than measurement of alkaline phosphatases (AP). Use of this technique for 83 patients with Hodgkin's disease revealed that the presence of the alpha 1 fraction (alpha 1 AP) was very significantly correlated with the stage of disease extension (P less than 0.01) and above all with the presence of general symptoms (P less than 0.001). Repeat measurements performed during patient follow-up demonstrated a close association between presence of alpha 1 AP and existence of progressive disease. While the mechanism of appearance of this abnormal alpha 1 AP fraction is not linked to Hodgkin-specific liver lesions, this test provides much more interesting data than classical measurement of total alkaline phosphatases (TAP).
电泳同工酶分离比碱性磷酸酶（AP）测定能提供更精确的信息。对83例霍奇金病患者使用该技术发现，α1组分（α1 AP）的存在与疾病扩展阶段显著相关（P＜0.01），最重要的是与全身症状的存在相关（P＜0.001）。在患者随访期间进行的重复测量表明，α1 AP的存在与疾病进展密切相关。虽然这种异常α1 AP组分出现的机制与霍奇金病特异性肝损伤无关，但该检测比传统的总碱性磷酸酶（TAP）测定提供了更有趣的数据。
