Biomechanical platelet activation: diseases that require a new class of antiplatelet therapeutics.

Mechanisms of platelet activation have traditionally been investigated through the activation of biochemical pathways through cell surface agonists such as adenosine diphosphate, thrombin, and collagen. However, recent research has identified another crucial mechanism, biomechanical activation, where external physical forces directly influence platelet reactivity. This paradigm shift underscores the complex interplay between biochemical and biomechanical stimuli in platelet activation. This review aims to understand the molecular mechanisms underlying biomechanical activation and the implications for treating thrombotic disorders.