Gupta Riya, Alkhalfan Fahad, Wheeler Jason, Cameron Scott J
Section of Vascular Medicine, Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States.
Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute of Case Western Reserve University, Cleveland, Ohio, United States.
Am J Physiol Cell Physiol. 2025 Jun 1;328(6):C1831-C1836. doi: 10.1152/ajpcell.00228.2025. Epub 2025 Apr 24.
Mechanisms of platelet activation have traditionally been investigated through the activation of biochemical pathways through cell surface agonists such as adenosine diphosphate, thrombin, and collagen. However, recent research has identified another crucial mechanism, biomechanical activation, where external physical forces directly influence platelet reactivity. This paradigm shift underscores the complex interplay between biochemical and biomechanical stimuli in platelet activation. This review aims to understand the molecular mechanisms underlying biomechanical activation and the implications for treating thrombotic disorders.
传统上，血小板活化机制是通过细胞表面激动剂（如二磷酸腺苷、凝血酶和胶原蛋白）激活生化途径来研究的。然而，最近的研究发现了另一种关键机制，即生物力学活化，外部物理力直接影响血小板反应性。这种范式转变突显了血小板活化过程中生化和生物力学刺激之间复杂的相互作用。本综述旨在了解生物力学活化背后的分子机制及其对治疗血栓性疾病的意义。
