Nano and microstructured systems for the controlled release of agricultural inputs represent a significant advancement in sustainable agriculture. These technologies enable the encapsulation of nutrients and pesticides, ensuring gradual and targeted delivery while reducing waste and enhancing plant absorption. Biodegradable materials, such as chitosan and alginate, offer eco-friendly solutions that improve efficiency under challenging conditions, including salinity and drought. Recent innovations have led to increased crop productivity, reduced pesticide application, and improved soil remediation. For example, nanoparticles can adsorb heavy metals like cadmium and lead, facilitating the restoration of contaminated soils. Despite these benefits, challenges remain, including the need for clear regulatory frameworks and further research on the long-term ecological impacts of nanomaterials. This review highlights the critical role of nano and microstructured systems in advancing agricultural sustainability. By bridging technological innovation with practical applications, these systems have the potential to transform global farming, making it more efficient, resilient, and environmentally sustainable.