Budde R, Günther M, Schaefer H E, Fischer R
Anal Quant Cytol. 1982 Mar;4(1):25-32.
Certain similarities in the cytoplasmic structure could indicate a histogenetic affinity between thyrocytes and pigmented macrophages in thyroid glands. On the other hand, the monocytogenic origin of macrophages in other organs in the body contradicts this assumption. We investigated these cells in smears of thyroid aspirates as well as in imprints, frozen sections and paraffin-embedded sections of freshly removed thyroid glands, using several cytochemical reactions and the usual panoptic stains. With the sodium-fluoride-inhibited alpha-naphthyl acetate esterase and tartrate-inhibited acid phosphatase reactions, the pigmented macrophages exhibited enzyme cytochemical patterns corresponding to those of blood monocytes or monocytogenic histiocytes but differing definitely from those of thyrocytes. Furthermore, we observed macrophages that exhibited a clearly monocytoid nuclear form and chromatin pattern in the interstitial space of the thyroid gland. These findings practically exclude a derivation of thyroidal pigmented macrophages from follicular epithelial cells and positively underline their derivation from blood monocytes.
甲状腺细胞胞质结构中的某些相似性可能表明甲状腺细胞与甲状腺中色素性巨噬细胞之间存在组织发生学上的亲缘关系。另一方面，身体其他器官中巨噬细胞的单核细胞起源与这一假设相矛盾。我们使用几种细胞化学反应和常规的全景染色法，对甲状腺抽吸物涂片以及新鲜切除的甲状腺的印片、冰冻切片和石蜡包埋切片中的这些细胞进行了研究。通过氟化钠抑制的α-萘乙酸酯酶反应和酒石酸盐抑制的酸性磷酸酶反应，色素性巨噬细胞呈现出与血液单核细胞或单核细胞源性组织细胞相对应的酶细胞化学模式，但与甲状腺细胞的模式明显不同。此外，我们在甲状腺间质中观察到巨噬细胞呈现出明显的单核样核形态和染色质模式。这些发现实际上排除了甲状腺色素性巨噬细胞来源于滤泡上皮细胞的可能性，并明确证实它们来源于血液单核细胞。
