Ilani Philip, Nyarko Prince B, Camara Abdouramane, Amenga-Etego Lucas N, Aniweh Yaw
West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Laboratory of Pathogens and Host Immunity (LPHI), CNRS, University of Montpellier, Montpellier, France.
NPJ Vaccines. 2025 Apr 24;10(1):82. doi: 10.1038/s41541-025-01137-6.
The search for potent malaria vaccine candidate has seen several twists and turns. Here, we provide a perspective on the current state of PfRH5-based malaria vaccine development, the progress, existing challenges, and future research directions. We discuss the clinical trials in endemic regions, immune correlates of protection, prospects of integrating PfRH5 into multi-antigen vaccine strategies and considerations on the onward development/deployment of PfRH5 vaccine from the laboratory to endemic communities.
寻找有效的疟疾疫苗候选物历经了诸多波折。在此，我们对基于疟原虫红细胞结合蛋白5（PfRH5）的疟疾疫苗研发现状、进展、现存挑战及未来研究方向进行了展望。我们讨论了在疟疾流行地区开展的临床试验、保护的免疫相关因素、将PfRH5整合到多抗原疫苗策略中的前景，以及关于PfRH5疫苗从实验室到流行社区的进一步研发/部署的考量。
