Ljunghall S, Danielson B G, Fellström B, Holmgren K, Johansson G, Wikström B
Br J Urol. 1985 Aug;57(4):370-4. doi: 10.1111/j.1464-410x.1985.tb06290.x.
A survey was carried out on the family history of renal stones among 380 patients in an out-patient stone clinic, most of whom had experienced frequent recurrences. In 55.4% of patients at least one first-degree relative had experienced renal stones. A positive family history was more common in females (64.7%) than in males (51.0%) and was particularly apparent in those who had multiple recurrences. It was also significantly more common in female patients with evidence of renal tubular defects (incomplete forms of renal tubular acidosis). Among the ordinary stone patients 18% of the fathers and 8% of the mothers had also formed renal stones. The corresponding figures for female stone patients with renal tubular defects were 40 and 33% respectively. These findings indicate that tubular dysfunction could be an inherited trait that predisposes to the formation of renal stones. Hypercalciuria or hyperuricosuria was not over-represented among stone formers with a positive family history.
对一家门诊结石诊所的380例患者进行了肾结石家族史调查，其中大多数患者有频繁复发史。在55.4%的患者中，至少有一位一级亲属曾患肾结石。阳性家族史在女性（64.7%）中比在男性（51.0%）中更常见，在那些有多次复发的患者中尤为明显。在有肾小管缺陷（不完全形式的肾小管酸中毒）证据的女性患者中也明显更常见。在普通结石患者中，18%的父亲和8%的母亲也患过肾结石。有肾小管缺陷的女性结石患者的相应数字分别为40%和33%。这些发现表明，肾小管功能障碍可能是一种遗传特征，易导致肾结石的形成。高钙尿症或高尿酸尿症在有阳性家族史的结石形成者中并不占优势。
