Liu Bo-Xi, Shah Syed Anis Ali, Zhou Feng, Rao Weidong, Shen Shu-Su, Sheng Daopeng, Wang Shun-Yi
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China.
Key Laboratory of Biomass-based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Org Lett. 2025 May 9;27(18):4656-4662. doi: 10.1021/acs.orglett.5c00899. Epub 2025 Apr 24.
A visible-light-induced trifunctionalization of unactivated alkenes for building functionalized oxindoles through a radical cyano migration strategy is reported. This transformation employs a tandem alkene sulfonylation-initiated cyano migration/cyclization cascade process. This strategy features stable and easily accessible substrates, mild reaction conditions, metal-free catalysts, and the capability of late-stage functionalization.
报道了一种通过自由基氰基迁移策略实现未活化烯烃的可见光诱导三官能化反应，用于构建官能化的氧化吲哚。该转化采用串联的烯烃磺酰化引发的氰基迁移/环化级联过程。此策略具有底物稳定且易于获得、反应条件温和、无金属催化剂以及后期官能化能力等特点。
