Cui Le, Gao Na, Bai Cairong, Zuo Yali, Hao Wendong, Guan Kai
Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, Peking Union Medical College Hospital, Beijing, China.
Front Allergy. 2025 Apr 10;6:1559201. doi: 10.3389/falgy.2025.1559201. eCollection 2025.
Prophylactic treatment for pollinosis is advantageous for managing nasal symptoms in patients with seasonal allergic rhinitis. Inadequate control of rhinitis symptoms increases the risk of acute asthma attacks. Nevertheless, there is limited research on the use of nasal glucocorticoids and antihistamines for the preventive treatment of pollinosis.
This study aimed to assess the efficacy of prophylactic treatment for nasal symptoms and acute asthma attacks by enrolling patients with pollinosis to use a combined device of azelastine hydrochloride and fluticasone nasal spray prior to the pollen season.
The study was registered at Chictr.org.cn (ChiCTR2300073758). A total of 120 patients with pollinosis were randomly assigned to either a prophylactic treatment group or a control group at a 1:1 ratio. In the prophylactic treatment group, the nasal spray was initiated approximately two weeks before the onset of the pollen season.
During both the pollen season and the concurrent medication period, the prophylactic treatment group presented significantly lower total nasal symptom scores (TNSS) (means of 5.97 and 5.94) than the control group (means of 7.86 and 7.80) ( = 0.015 and 0.016). Although the prophylactic treatment group had a lower asthma attack rate than the control group, the difference was not statistically significant ( = 0.284).
Prophylactic treatment with azelastine hydrochloride and fluticasone propionate nasal sprays can alleviate nasal symptoms and may reduce acute asthma attacks during the pollen season.
[Chictr.org.cn], identifier (ChiCTR2300073758).
花粉症的预防性治疗有利于控制季节性过敏性鼻炎患者的鼻部症状。鼻炎症状控制不佳会增加急性哮喘发作的风险。然而，关于使用鼻用糖皮质激素和抗组胺药预防性治疗花粉症的研究有限。
本研究旨在通过招募花粉症患者在花粉季节前使用盐酸氮卓斯汀和氟替卡松鼻喷雾剂的联合装置，评估其对鼻部症状和急性哮喘发作的预防性治疗效果。
该研究在Chictr.org.cn（ChiCTR2300073758）注册。总共120例花粉症患者按1:1比例随机分为预防性治疗组或对照组。在预防性治疗组中，鼻喷雾剂在花粉季节开始前约两周开始使用。
在花粉季节和同时用药期间，预防性治疗组的总鼻症状评分（TNSS）（均值分别为5.97和5.94）均显著低于对照组（均值分别为7.86和7.80）（P = 0.015和0.016）。虽然预防性治疗组的哮喘发作率低于对照组，但差异无统计学意义（P = 0.284）。
盐酸氮卓斯汀和丙酸氟替卡松鼻喷雾剂预防性治疗可减轻鼻部症状，并可能减少花粉季节的急性哮喘发作。
[Chictr.org.cn]，标识符（ChiCTR2300073758）。
