通过基于前药的探针的生物转化鉴定番泻苷A的泻下靶点。
Identifying purgative targets of sennoside A via biotransformation of prodrug-based probes.
作者信息
Liu Zhen, Geng Xinyue, Liu Xinyue, Li Mengru, Li Xiang, Zhang Zhixin, Luo Gan, Wang Ying, Gao Xiaoyan
机构信息
Department of Chinese Medicine Analysis, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.
出版信息
J Pharm Anal. 2025 Apr;15(4):101078. doi: 10.1016/j.jpha.2024.101078. Epub 2024 Aug 23.
Abstract
•A strategy for metabolically synthesized active drug-based probes was proposed.•The potential purgative targets of SA were successfully hooked and identified.•The work provided a new insight for studying the direct targets of unstable active drugs.
摘要
•提出了一种基于代谢合成活性药物的探针策略。
•成功锁定并鉴定了SA潜在的致泻靶点。
•这项工作为研究不稳定活性药物的直接靶点提供了新的见解。
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