Kanakoudi-Tsakalidis F, Spyroglou K, Tzafi R, Cassimos C
Acta Haematol. 1977;57(2):65-73. doi: 10.1159/000207861.
The effect of blood transfusions on the immune response of 46 thalassaemic children was studied. Cell-mediated immune response was evaluated by performing skin tests to specific (streptokinase-streptodornase and candidin) and nonspecific (dinitrochlorobenzene and phytohaemagglutinin) antigens. Antibody response to specific antigen (tetanus toxoid) was estimated by measuring the tetanus antitoxin titre before and after vaccination. No gross impairment of cell-mediated immunity was elicited. The larger proportion of negative phytohaemagglutinin skin tests found in thalassaemic patients does not necessarily suggest a cell-mediated immunity impairment, since this skin reaction is also affected by other factors, especially the inflammatory skin response. The transfused antibodies may inhibit the recipient's sensitization and primary immune response to the homologous antigen, especially when the antibody level in the transfused blood is high whereas the secondary immune response is not affected.
研究了输血对46名地中海贫血儿童免疫反应的影响。通过对特异性（链激酶-链道酶和念珠菌素）和非特异性（二硝基氯苯和植物血凝素）抗原进行皮肤试验来评估细胞介导的免疫反应。通过测量接种疫苗前后的破伤风抗毒素滴度来评估对特异性抗原（破伤风类毒素）的抗体反应。未引发细胞介导免疫的严重损害。在地中海贫血患者中发现较大比例的植物血凝素皮肤试验阴性，这不一定表明细胞介导的免疫受损，因为这种皮肤反应也受其他因素影响，尤其是炎症性皮肤反应。输入的抗体可能会抑制受者对同源抗原的致敏和初次免疫反应，特别是当输入血液中的抗体水平较高时，而二次免疫反应则不受影响。
