Vierucci A, London W T, Blumberg B S, Sutnick A I, Ragazzini F
Arch Dis Child. 1972 Oct;47(255):760-5. doi: 10.1136/adc.47.255.760.
As a consequence of frequent transfusions, 10% of 169 Italian patients with thalassaemia developed Au(1) and 20% anti-Au(1). Au(1) persisted in the children in whom it was detected for the duration of the study (2-7 years) or until the patient died. Anti-Au(1) was less persistent. In these children, Au(1) or anti-Au(1) was detected, but not both, suggesting that patients with persistent Au(1) and antibody formers represent two distinct subgroups of the thalassaemia population. Au(1) was more common in males and in patients less than 7 years old, and was associated with earlier death; whereas antibody was more common in females, and in children older than 7 years, and was associated with longer survival.
由于频繁输血，169名意大利地中海贫血患者中有10%产生了Au(1)，20%产生了抗Au(1)。在研究期间（2至7年）或患者死亡前，Au(1)在被检测出的儿童中持续存在。抗Au(1)的持续时间较短。在这些儿童中，只检测到了Au(1)或抗Au(1)，而不是两者都有，这表明持续存在Au(1)的患者和产生抗体的患者代表了地中海贫血人群中的两个不同亚组。Au(1)在男性和7岁以下患者中更为常见，且与较早死亡相关；而抗体在女性和7岁以上儿童中更为常见，且与较长生存期相关。
