Omić Haris, Eskandary Farsad, Beitzke Dietrich, Wolf Marcos, Kozakowski Nicolas, Böhmig Georg, Beck-Tölly Andrea, Eder Michael
Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Division of Cardiovascular and Interventional Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Transpl Int. 2025 Apr 10;38:14301. doi: 10.3389/ti.2025.14301. eCollection 2025.
Quantitative magnetic resonance imaging (MRI) is emerging as a non-invasive tool to measure tissue scarring in renal allografts. However, whether prolonged T relaxation time results in lower transplant survival rates is unknown. This retrospective cohort study analyzed the capability to predict renal allograft dysfunction based on median T time. Forty-six transplant recipients with non-contrast 1.5T MRI and allograft biopsy were included. The primary endpoint was the eGFR slope over 24 months. T relaxation time correlated significantly with eGFR levels at all follow-up stages. Patients with T relaxation time above the median (T ) had a consistent decline in kidney function as compared to the patient group below the median (T ): overall eGFR slope: 11.3 vs. 1.4 mL/min/1.73 m over 24 months, p = 0.016. Graft survival rates at 24 months were 52% in the T vs. 87% in the T group, p = 0.0015. ROC analysis discovered a positive predictive value of 52% and a negative predictive value of 91% for graft loss. T mapping identified patients with a persistent decline of allograft function and an increased risk of allograft loss. MRI could significantly influence monitoring strategies in transplant surveillance, offering a safe, non-invasive alternative to traditional diagnostic methods.
定量磁共振成像（MRI）正逐渐成为一种用于测量肾移植组织瘢痕形成的非侵入性工具。然而，T弛豫时间延长是否会导致移植存活率降低尚不清楚。这项回顾性队列研究分析了基于T中位数预测肾移植功能障碍的能力。纳入了46例接受非增强1.5T MRI检查和移植肾活检的移植受者。主要终点是24个月内的估算肾小球滤过率（eGFR）斜率。T弛豫时间在所有随访阶段均与eGFR水平显著相关。T弛豫时间高于中位数（T）的患者与低于中位数（T）的患者组相比，肾功能持续下降：24个月内总体eGFR斜率分别为11.3和1.4 mL/min/1.73 m²，p = 0.016。T组24个月时的移植存活率为52%，而T组为87%，p = 0.0015。ROC分析发现移植肾丢失的阳性预测值为52%，阴性预测值为91%。T映射可识别移植肾功能持续下降且移植肾丢失风险增加的患者。MRI可显著影响移植监测中的监测策略，为传统诊断方法提供一种安全、非侵入性的替代方法。
