Shen Wei, Ye Qilian, Zhang Hongbo, Xie Shenghong, Xie Shiqi, Chen Cailian, Liu Jinying, Huang Zhengwei, Luo Hai-Bin, Guo Ling
Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, No 1. Mingde Road, Donghu District, Nanchang 330006, China.
J Funct Biomater. 2025 Apr 1;16(4):124. doi: 10.3390/jfb16040124.
Psoriasis is a chronic and recurrent inflammatory disease driven not only by intrinsic factors such as immune system dysregulation but also by external factors, including bacterial infections. In contrast to the control of a single pathogenic pathway, combination therapies addressing both the immune and infectious components of psoriasis pathogenesis may offer a more effective strategy for controlling its progression. In this study, we developed a sprayable hydrogel incorporating tea polyphenol-loaded lauric acid liposomes (TP@LA-Lipo gel) to investigate its anti-inflammatory and antibacterial role in psoriasis. Our results demonstrated that TP@LA-Lipo modulated macrophage activity, reduced the expression of iNOS and TNF-α, and remodeled the immune microenvironment. Meanwhile, TP@LA-Lipo effectively eliminated and through membrane disruption, mitigating the provoked inflammatory response. More importantly, TP@LA-Lipo gel, when sprayed onto the psoriasis lesions, provided sustained drug release over three days, enabling deeper penetration through the thickened stratum corneum to reach the inflamed layers beneath. Furthermore, in an imiquimod-induced psoriasis mouse model, TP@LA-Lipo gel effectively restored the damaged skin, alleviated histopathological changes, and reduced the systemic immune response. In summary, these findings indicate that TP@LA-Lipo gel offers a comprehensive strategy for effective disease management and improving the quality of life for psoriasis patients.
银屑病是一种慢性复发性炎症性疾病，不仅由免疫系统失调等内在因素驱动，还受包括细菌感染在内的外部因素影响。与单一致病途径的控制不同，针对银屑病发病机制的免疫和感染成分的联合疗法可能为控制其进展提供更有效的策略。在本研究中，我们开发了一种包含负载茶多酚的月桂酸脂质体的可喷雾水凝胶（TP@LA-Lipo凝胶），以研究其在银屑病中的抗炎和抗菌作用。我们的结果表明，TP@LA-Lipo调节巨噬细胞活性，降低iNOS和TNF-α的表达，并重塑免疫微环境。同时，TP@LA-Lipo通过膜破坏有效地消除了 并减轻了引发的炎症反应。更重要的是，TP@LA-Lipo凝胶喷洒在银屑病皮损上时，能在三天内持续释放药物，使其能够更深入地穿透增厚的角质层到达下方的炎症层。此外，在咪喹莫特诱导的银屑病小鼠模型中，TP@LA-Lipo凝胶有效地修复了受损皮肤，减轻了组织病理学变化，并降低了全身免疫反应。总之，这些发现表明，TP@LA-Lipo凝胶为有效管理疾病和改善银屑病患者的生活质量提供了一种全面的策略。
