Hill G B, Fincham S M, Wijayasinghe C, Haronga C L, Hendin M M
CMAJ. 1985 Sep 15;133(6):567-71.
We have examined the fertility of 354 patients with prostatic cancer and 597 controls who had married at least once and formed part of a population-based case-control study in Alberta. Considering offspring of both sexes, the mean fertility of the patients was 3.17, not significantly different from the mean of 3.11 for the controls. However, the sex ratios were significantly different, 56.5% of the patients' offspring being sons, compared with 50.1% of the controls' offspring. The difference in sex ratio persisted after adjustment for ethnic group, level of education and age at first marriage, which were found to be risk factors for prostatic cancer.
我们对354名前列腺癌患者和597名对照者的生育能力进行了研究，这些对照者都至少结过一次婚，是阿尔伯塔省一项基于人群的病例对照研究的一部分。考虑到两性后代，患者的平均生育能力为3.17，与对照者的平均生育能力3.11没有显著差异。然而，性别比例存在显著差异，患者后代中有56.5%是儿子，而对照者后代中这一比例为50.1%。在对种族、教育水平和初婚年龄进行调整后，性别比例的差异仍然存在，而这些因素被发现是前列腺癌的风险因素。
