Armenian H K, Lilienfeld A M, Diamond E L, Bross I D
Am J Epidemiol. 1975 Jul;102(1):47-54. doi: 10.1093/oxfordjournals.aje.a112133.
A case-control study was conducted between 1957 and 1965 on 128 patients with benign prostatic hyperplasia (BPH), 256 age-matched controls, 290 prostate cancer patients and 290 age-matched controls for the prostate cancer patients, all of whom had completed the Roswell Park Memorial Institute epidemiology questionnaire and were interviewed on admission to the Institute. Compared to the control groups a higher proportion of both case groups were Protestants and residents of smaller towns. The major finding in this case-control study was a significantly higher risk for prostate cancer in fertile males compared to both married and non-married, but infertile males. This finding was confirmed when fertility was used as a variable for the classification of study groups in an earlier prospective study reporting the follow-up of patients with BPH and non-neoplastic controls. In this study, patients with children were found to have a relative risk of 2.69 for prostate cancer compared to the married patients with no children. Fertility may be a manifestation of constitutional-hormonal factors that increase the risk of prostate cancer.
1957年至1965年间，针对128例良性前列腺增生（BPH）患者、256例年龄匹配的对照者、290例前列腺癌患者以及290例年龄匹配的前列腺癌患者对照者开展了一项病例对照研究。所有这些人都完成了罗斯韦尔帕克纪念研究所的流行病学调查问卷，并在入院时接受了访谈。与对照组相比，两个病例组中较高比例的人是新教徒且居住在小镇。这项病例对照研究的主要发现是，与已婚但不育以及未婚不育的男性相比，生育过的男性患前列腺癌的风险显著更高。当在一项早期前瞻性研究中将生育情况用作研究组分类变量时，这一发现得到了证实，该前瞻性研究报告了BPH患者和非肿瘤对照者的随访情况。在这项研究中，有孩子的患者与没有孩子的已婚患者相比，患前列腺癌的相对风险为2.69。生育情况可能是增加前列腺癌风险的体质 - 激素因素的一种表现。
