Davy M, Mossige J, Johannessen J V
Acta Obstet Gynecol Scand. 1977;56(1):55-9. doi: 10.3109/00016347709158340.
Successful heterotransplantation of ovarian cancer in the mouse mutant, nude is described, with serial transmission, in one case to date. Light and electron microscopic examination of this tumour, a poorly differentiated adenocarcinoma, has not revealed any alteration in its morphology after six passages. Tumour-bearing mice have been treated with ThioTEPA or 5-Fluoro-Uracil, in an attempt to see if they show a similar effect to that seen in the patient. ThioTEPA resulted in a marked regression, whilst there was no effect from 5-Fluoro-Uracil, on tumour growth--confirming the ThioTEPA effect seen in the patient.
本文描述了在裸鼠这一突变小鼠中成功进行的卵巢癌异种移植，并实现了连续传代，目前已有一例。对该肿瘤（一种低分化腺癌）进行光镜和电镜检查发现，经过六代传代后其形态未发生任何改变。对荷瘤小鼠使用了塞替派或5-氟尿嘧啶进行治疗，试图观察它们是否会产生与患者身上所见类似的效果。塞替派导致肿瘤显著消退，而5-氟尿嘧啶对肿瘤生长没有影响，这证实了在患者身上观察到的塞替派效果。
