Pérez-Rubio Gloria, Falfán-Valencia Ramcés, Bravo-Gutiérrez Omar Andrés, Lozano-González Nancy, Ramírez-Venegas Alejandra, Cruz-Vicente Filiberto, Ramírez-Díaz María Elena
HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
Tobacco Smoking and COPD Research Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
Toxics. 2025 Mar 28;13(4):253. doi: 10.3390/toxics13040253.
COPD induced by biomass-burning smoke is a public health problem in developing countries. Biomass-based fuels are ineffective and deliver elevated levels of carbon monoxide, polycyclic aromatic hydrocarbons, and fine particulate matter. participates in extracellular matrix remodeling processes in COPD patients. Our objective was to estimate the DNA methylation levels of cg23771366 () and their clinical relevance in COPD caused by chronic exposure to biomass-burning smoke (BBS). We included 80 women with COPD (COPD-BBS) (≥200 h per year), 180 women with exposure to BBS (≥200 h per year) but without COPD (BBES), and 79 lung-healthy women (HW) without exposure to biomass-burning smoke. The DNA methylation analysis shows significant differences between the three groups included in this study ( < 0.001). HW had high methylation levels (100%) in cg23771366 (). In comparison, COPD-BBS and BBES had low levels [0.91% vs. 9.17%, respectively], showing statistically significant differences ( = 0.011) between both groups, with the COPD-BBS presenting the lowest levels in the methylation of cg23771366. In conclusion, chronic biomass-burning smoke exposure is associated with decreased levels of DNA methylation at the CpG cg23771366 site in , reinforcing the relationship between and particulate matter.
生物质燃烧烟雾引起的慢性阻塞性肺疾病（COPD）是发展中国家的一个公共卫生问题。基于生物质的燃料效率低下，会释放出高水平的一氧化碳、多环芳烃和细颗粒物。[此处原文有缺失内容，可能影响完整理解]参与慢性阻塞性肺疾病患者的细胞外基质重塑过程。我们的目的是评估cg23771366（）的DNA甲基化水平及其在长期暴露于生物质燃烧烟雾（BBS）所致慢性阻塞性肺疾病中的临床相关性。我们纳入了80名患有慢性阻塞性肺疾病（COPD - BBS）（每年暴露≥200小时）的女性、180名暴露于生物质燃烧烟雾（每年暴露≥200小时）但未患慢性阻塞性肺疾病（BBES）的女性以及79名未暴露于生物质燃烧烟雾的肺部健康女性（HW）。DNA甲基化分析显示本研究纳入的三组之间存在显著差异（<0.001）。HW在cg23771366（）中具有高甲基化水平（100%）。相比之下，COPD - BBS和BBES的水平较低[分别为0.91%和9.17%]，两组之间显示出统计学显著差异（=0.011），其中COPD - BBS在cg23771366的甲基化水平最低。总之，长期暴露于生物质燃烧烟雾与在CpG cg23771366位点的DNA甲基化水平降低有关，加强了[此处原文有缺失内容，可能影响完整理解]与颗粒物之间的关系。
