Amin Yahia A, Shanab Obeid, Zahran Ibrahim S, Farrag Foad, Fawy Mariam A, Shukry Mustafa, Abdelmegeid Mohamed, Abu El-Naga Eman M, Mohamed Ragab H, Elolimy Ahmed A
Department of Theriogenology, Faculty of Veterinary Medicine, Aswan University, Aswan, Egypt.
Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
Vet Med Sci. 2025 May;11(3):e70304. doi: 10.1002/vms3.70304.
Foetal mummification does not cause loss by losing foetus only but the harm extends to the mother dam. This is the first study that investigates the changes that occur in the dam's body due to foetal mummification through a comprehensive investigation of the hormonal, biochemical, liver, kidney and mineral profiles of the dam. This study represents a model to investigate the pathogenesis of such clinically severe cases.
This study involved 40 cows with foetal mummification. The dams were divided into 2 groups (20 for each): Group 1 (cows carrying normal foetuses [CNF]) and Group 2 (cows carrying mummified foetuses [CMF]). Blood samples were collected for evaluation of hormonal profile, biochemical profile, kidney profile, liver profile and mineral profile.
Results showed that progesterone (P4) and oestradiol (E2) concentrations were not significantly changed in the CMF group compared to the CNF group, whereas total triiodothyronine (T3) and total thyroxin (T4) showed a significant reduction in mummified cases than in CNF group. In the CMF group, parameters such as glucose and albumin were significantly lower compared to the normal pregnant animals. In contrast, triglycerides, cholesterol, globulin and total protein (TP) were significantly higher. Kidney and liver profiles showed a significant increase in urea, aspartate aminotransferase (AST), alkaline phosphatase (ALP) and bilirubin, a significant decrease in alanine aminotransferase (ALT) and non-significant differences in creatinine and gamma-glutamyl transpeptidase (GGT) in CMF compared with normal pregnant cows. Mineral profiles showed a significant decrease in calcium and phosphorus, a significant increase in iron and potassium and a non-significant increase in magnesium, sodium and chloride in the mummified group compared to the normal pregnancy group.
Cows with mummified foetuses (MF) maintained variant biological changes in the body. These findings can be used as an indicator for cow health and as a diagnostic tool to avoid pregnancy disorders that occur during the late pregnancy.
胎儿干尸化不仅导致胎儿丢失，其危害还会波及母体。本研究首次通过全面检测母体的激素、生化、肝脏、肾脏及矿物质指标，探究胎儿干尸化对母体身体造成的变化。本研究为调查此类临床严重病例的发病机制提供了一个模型。
本研究纳入40头发生胎儿干尸化的奶牛。将这些母体分为两组（每组20头）：第1组（怀有正常胎儿的奶牛[CNF]）和第2组（怀有干尸化胎儿的奶牛[CMF]）。采集血样以评估激素水平、生化指标、肾脏指标、肝脏指标和矿物质指标。
结果显示，与CNF组相比，CMF组的孕酮（P4）和雌二醇（E2）浓度无显著变化，而总三碘甲状腺原氨酸（T3）和总甲状腺素（T4）在干尸化病例中较CNF组显著降低。在CMF组中，葡萄糖和白蛋白等参数显著低于正常怀孕动物。相比之下，甘油三酯、胆固醇、球蛋白和总蛋白（TP）显著升高。与正常怀孕奶牛相比，CMF组的肾脏和肝脏指标显示尿素、天冬氨酸转氨酶（AST）、碱性磷酸酶（ALP）和胆红素显著升高，丙氨酸转氨酶（ALT）显著降低，肌酐和γ-谷氨酰转肽酶（GGT）无显著差异。矿物质指标显示，与正常怀孕组相比，干尸化组的钙和磷显著降低，铁和钾显著升高，镁、钠和氯无显著升高。
怀有干尸化胎儿（MF）的奶牛身体存在多种生物学变化。这些发现可作为奶牛健康的指标以及避免晚期妊娠期间发生妊娠紊乱的诊断工具。
Zotero 插件
