Amin Yahia A, Mahmoud Alaa Eldin Z, Ali Rana A, Fouad Samer S, Shanab Obeid, Ibrahim Rawia M, Farrag Foad, Shukry Mustafa, Ibrahim Samah F, Fericean Liana, Mohamed Ragab Hassan
Department of Theriogenology, Faculty of Veterinary Medicine, Aswan University, Aswan 81528, Egypt.
Department of Theriogenology, Faculty of Veterinary Medicine, Sohag University, Sohag 82524, Egypt.
Animals (Basel). 2023 Feb 13;13(4):653. doi: 10.3390/ani13040653.
This study was designed to evaluate a new therapeutic approach for inactive ovaries based on the epidural administration of a GnRH agonist (Receptal) and an investigation of the impact of this treatment on the hormonal, oxidant/antioxidant and micro- and macro-element profiles. Sixty cows with postpartum anestrus were divided into two groups: the first group (group R, n = 30) was administered an epidural injection of Receptal, while the second group (group C, n = 30) received saline and was considered the control group. Evaluation of hormonal (progesterone, FSH, LH, testosterone, and cortisol), oxidant/antioxidant (MDA, SOD, GPx and TAC) as well as micro- and macroelement (calcium, phosphorus, manganese and magnesium) profiles was done in serum. The results showed that the epidural injection of Receptal has the potential to induce estrus response and conception incidence in treated cows. Compared to the control group, progesterone, FSH, and LH concentrations were significantly increased in the treated group, whereas testosterone and cortisol decreased ( < 0.05) following treatment. In addition, the treated group had greater TAC and GPx concentrations than the control group. Serum concentrations of magnesium increased ( < 0.05) following receptal treatment, but differences in other minerals were not detected. This research suggests a novel, effective method of treating inactive ovaries with epidural infusion of a GnRH agonist.
本研究旨在评估基于硬膜外注射促性腺激素释放激素激动剂（Receptal）治疗静止卵巢的新方法，并研究该治疗对激素、氧化/抗氧化以及微量元素和常量元素谱的影响。60头产后乏情奶牛被分为两组：第一组（R组，n = 30）接受硬膜外注射Receptal，而第二组（C组，n = 30）接受生理盐水注射，作为对照组。对血清中的激素（孕酮、促卵泡素、促黄体素、睾酮和皮质醇）、氧化/抗氧化指标（丙二醛、超氧化物歧化酶、谷胱甘肽过氧化物酶和总抗氧化能力）以及微量元素和常量元素（钙、磷、锰和镁）谱进行评估。结果表明，硬膜外注射Receptal有可能诱导治疗奶牛出现发情反应和受孕率。与对照组相比，治疗组的孕酮、促卵泡素和促黄体素浓度显著升高，而治疗后睾酮和皮质醇降低（P<0.05）。此外，治疗组的总抗氧化能力和谷胱甘肽过氧化物酶浓度高于对照组。Receptal治疗后血清镁浓度升高（P<0.05），但未检测到其他矿物质的差异。本研究提示硬膜外输注促性腺激素释放激素激动剂是一种治疗静止卵巢的新颖、有效方法。
