Wynder E L, Lahti H, Laakso K, Cheng S L, DeBevoise S, Rose D P
Cancer. 1985 Sep 15;56(6):1473-8. doi: 10.1002/1097-0142(19850915)56:6<1473::aid-cncr2820560642>3.0.co;2-m.
Epidemiologic data were obtained, and nipple aspiration attempted, from 289 healthy women, 548 women currently having or with a history of benign breast disease, 153 untreated women with breast cancer, and 106 women previously treated by mastectomy. Breast duct fluid was produced in detectable amounts by 59% of the controls and patients with benign or untreated malignant breast disease; in 35% the volume was in excess of 10 microliters. There were more secretors aged 30 to 50 years (72%), than either those who were younger (52%), or older (44%). Overall, 57% of premenopausal women were secretors, compared with 38% of postmenopausal women. Healthy women who had their menarche before age 13 years were more likely to be secretors. Neither parity, age at first completed pregnancy, nor body weight affected secretor status. There was a trend for the 141 benign breast disease patients aged 40 to 49 years to include more women yielding greater than 10 microliter of fluid (57%) compared with 46 controls (39%). Although breast cancer per se did not appear to influence secretor status, postmastectomy patients were more likely to secrete large fluid volumes, an effect that was particularly pronounced after menopause. Hormonal factors related to age and fibrocystic disease risk and endocrine activity after mastectomy may be the principal determinants influencing the secretion of breast duct fluid.
我们获取了289名健康女性、548名患有良性乳腺疾病或有该疾病病史的女性、153名未经治疗的乳腺癌女性以及106名曾接受乳房切除术的女性的流行病学数据，并尝试进行乳头抽吸。59%的对照组女性以及患有良性或未经治疗的恶性乳腺疾病的患者能够产生可检测量的乳腺导管液；其中35%的量超过10微升。年龄在30至50岁的分泌者（72%）比年龄较小者（52%）或较大者（44%）更多。总体而言，57%的绝经前女性是分泌者，而绝经后女性为38%。月经初潮在13岁之前的健康女性更有可能是分泌者。生育次数、首次足月妊娠时的年龄以及体重均不影响分泌者状态。141名年龄在40至49岁的良性乳腺疾病患者中，与46名对照组女性（39%）相比，产生超过10微升液体的女性更多（57%），存在一种趋势。虽然乳腺癌本身似乎不影响分泌者状态，但乳房切除术后的患者更有可能分泌大量液体，这种效应在绝经后尤为明显。与年龄、纤维囊性疾病风险相关的激素因素以及乳房切除术后的内分泌活动可能是影响乳腺导管液分泌的主要决定因素。
