Yang Mingpeng, Wang Chaofan, Cai Jun, Lai Xiaochen, Cao Mingyi, Zhao Xingqiang
School of Automation, Nanjing University of Information Science and Technology, 219 Ningliu Road, Nanjing, 210044, China.
Jiangsu Collaborative Innovation Centre On Atmospheric Environment and Equipment Technology, Nanjing University of Information Science and Technology, 219 Ningliu Road, Nanjing, 210044, China.
Anal Sci. 2025 Apr 25. doi: 10.1007/s44211-025-00771-3.
Over the past three decades, microchip electrophoresis coupled with capacitively coupled contactless conductivity detection (ME-CD) has garnered considerable interest due to its various merits, including minimal sample consumption, compact structure, immediate detection, and high analytical precision. Continuous technological innovation and improvement have significantly advanced ME-CD in structural design, fabrication processes, and experimental methodologies. As a result, the application of this technology has expanded into a wider range of electrochemical analysis fields, including disease diagnosis, food safety assessment, environmental pollutant detection, and soil nutrient analysis. This review meticulously examines the forefront of ME-CD over the last five years. It methodically categorizes and scrutinizes advancements from various dimensions, including newly emerged ME microchips, CD electrodes, experimental protocols, and pioneering applications. Moreover, this paper critically summarizes these developments, identifying the prevailing limitations and challenges within ME-CD. Ultimately, it projects potential future trajectories for innovation in the field of ME-CD, suggesting pathways to overcome existing hurdles and hinting at the untapped possibilities that lie ahead.
在过去三十年中，微芯片电泳与电容耦合非接触式电导检测（ME-CD）相结合，因其具有多种优点而备受关注，这些优点包括样品消耗极少、结构紧凑、检测即时以及分析精度高。持续的技术创新和改进在结构设计、制造工艺和实验方法等方面极大地推动了ME-CD的发展。因此，该技术的应用已扩展到更广泛的电化学分析领域，包括疾病诊断、食品安全评估、环境污染物检测和土壤养分分析。本综述精心审视了过去五年中ME-CD的前沿进展。它系统地从各个维度对进展进行分类和审视，包括新出现的ME微芯片、CD电极、实验方案和开创性应用。此外，本文批判性地总结了这些发展，确定了ME-CD中存在的主要限制和挑战。最终，它预测了ME-CD领域未来潜在的创新轨迹，提出了克服现有障碍的途径，并暗示了未来尚未开发的可能性。
