Duffy Kelly A, Wiglesworth Andrea, Roediger Donovan J, Island Ellery, Mueller Bryon A, Luciana Monica, Klimes-Dougan Bonnie, Cullen Kathryn R, Fiecas Mark B
Department of Psychology, University of Minnesota, Elliott Hall, 75 East River Parkway, Minneapolis, MN 55455, USA.
Department of Psychology, University of Minnesota, Elliott Hall, 75 East River Parkway, Minneapolis, MN 55455, USA.
Neuroimage. 2025 Jun;313:121238. doi: 10.1016/j.neuroimage.2025.121238. Epub 2025 Apr 23.
Understanding the relative influences of age, pubertal development, and sex assigned at birth on brain development is a key priority of developmental neuroscience given the complex interplay of these factors in the onset of psychopathology. Previous research has investigated how these factors relate to static (time-averaged) functional connectivity (FC), but little is known about their relationship with dynamic (time-varying) FC. The present study aimed to investigate the unique and overlapping roles of these factors on dynamic FC in children aged approximately 9 to 14 in the ABCD Study using a sample of 5122 low-motion resting-state scans (from 4136 unique participants). Time-varying correlations in the frontolimbic, default mode, and dorsal and ventral corticostriatal networks, estimated using the Dynamic Conditional Correlations (DCC) method, were used to calculate variability of within- and between-network connectivity and of graph theoretical measures of segregation and integration. We found decreased variability in global efficiency across the age range, and increased variability within the frontolimbic network driven primarily by those assigned female at birth (AFAB). AFAB youth specifically also showed increased variability in several other networks. Controlling for age, both advanced pubertal development and being AFAB were associated with decreased variability in all within- and between-network correlations and increased variability in measures of network segregation. These results potentially suggest advanced brain maturation in AFAB youth, particularly in key networks related to psychopathology, and lay the foundation for future investigations of dynamic FC.
鉴于这些因素在精神病理学发病过程中的复杂相互作用，了解年龄、青春期发育和出生时指定的性别对大脑发育的相对影响是发育神经科学的一个关键优先事项。先前的研究已经调查了这些因素与静态（时间平均）功能连接（FC）的关系，但对于它们与动态（随时间变化）FC的关系却知之甚少。本研究旨在利用5122次低运动静息态扫描（来自4136名独特参与者）的样本，调查这些因素在ABCD研究中对约9至14岁儿童动态FC的独特和重叠作用。使用动态条件相关（DCC）方法估计的额边缘、默认模式以及背侧和腹侧皮质纹状体网络中的随时间变化的相关性，用于计算网络内和网络间连接性的变异性以及分离和整合的图论测量值。我们发现，在整个年龄范围内，全局效率的变异性降低，而额边缘网络内的变异性增加，这主要是由出生时被指定为女性（AFAB）的人驱动的。AFAB青少年在其他几个网络中也特别表现出变异性增加。在控制年龄后，青春期发育提前和为AFAB都与所有网络内和网络间相关性的变异性降低以及网络分离测量值的变异性增加有关。这些结果可能表明AFAB青少年的大脑成熟度较高，尤其是在与精神病理学相关的关键网络中，这为未来对动态FC的研究奠定了基础。
