Ching R, Geddes R, Simpson S A
Carbohydr Res. 1985 Jun 15;139:285-91. doi: 10.1016/0008-6215(85)90027-8.
The incorporation of radioactivity into liver glycogen has been shown not only to be a metabolically inhomogeneous process but also to depend critically on the nature of the precursor. D-Galactose is incorporated into glycogen by a mechanism which is separate from that associated with the incorporation of D-glucose. D-Galactose is favoured for incorporation into high-molecular-weight glycogen and consequently is affected more by treatment of the animal with the antibiotic tunicamycin, since high-molecular-weight glycogen is preferentially found in the lysosomal compartment.
放射性掺入肝糖原不仅被证明是一个代谢不均匀的过程，而且还严重依赖于前体的性质。D-半乳糖通过一种与D-葡萄糖掺入相关机制不同的机制掺入糖原。D-半乳糖更倾向于掺入高分子量糖原，因此在用抗生素衣霉素处理动物时受影响更大，因为高分子量糖原优先存在于溶酶体区室中。
