溶酶体对糖原代谢的影响。
The influence of lysosomes on glycogen metabolism.
作者信息
Geddes R, Stratton G C
出版信息
Biochem J. 1977 May 1;163(2):193-200. doi: 10.1042/bj1630193.
Abstract
Lysosome-rich fractions were isolated from rat liver homogenates. In some fractions the lysosomes were separated from the contaminating mitchondria by the use of discontinuous Ficoll/sucrose gradients. Some glycogen was associated with lysosome fractions. This glycogen was of very large molecular size and of a quite different molecular-weight distribution from that isolated from the cytosol. It is suggested that appreciably more than 10% of cellular glycogen is located within the lysosome.
摘要
从大鼠肝脏匀浆中分离出富含溶酶体的组分。在一些组分中，通过使用不连续的菲可/蔗糖梯度将溶酶体与污染的线粒体分离。一些糖原与溶酶体组分相关联。这种糖原分子尺寸非常大，其分子量分布与从细胞质溶胶中分离出的糖原截然不同。据推测，细胞内超过10%的糖原位于溶酶体内。
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