Gold Michael, Boyd Charles, Mraz Deanne, Robison Tiffany, Shafiq Faiza, Widgerow Alan D
Tennessee Clinical Research Center, Nashville, Tennessee, USA.
Boyd, Birmingham, Michigan, USA.
J Cosmet Dermatol. 2025 Apr;24(4):e70192. doi: 10.1111/jocd.70192.
Alastin Restorative Skin Complex Serum with TriHex Technology (Alastin Skincare Inc., Carlsbad, CA) has undergone reformulation to add Octapeptide-45 and magnolol for improving facial skin hydration, elasticity, plumping, and overall skin quality. Detailed science on TriHex Technology 2.0 and magnolol has been recently published. This open-label study was conducted to validate the science and demonstrate product efficacy and tolerability in individuals with moderate to severe facial skin aging.
A multi-center clinical study was conducted from February to August 2024. A total of 44 eligible participants (43 female, 1 male), ages 35-69 years, and Fitzpatrick skin Types I-VI were enrolled in and completed the study following 12 weeks of Alastin Restorative Skin Complex Serum 2.0 with TriHex Technology (RSC 2.0) use twice daily, along with an Alastin Skincare Inc. supportive regimen (cleanser, moisturizer, sunscreen used as needed). A 1-week run-in phase using the supportive regimen only was conducted, and eligibility was reassessed at baseline. Follow-up visits were performed at Weeks 4, 8, and 12, where facial skin quality parameters were evaluated clinically and subject assessments and satisfaction questionnaires, biopsy collection, photography, and hydration and elasticity measurements were completed. Participants also maintained a study diary over the 12-week treatment period.
Significant improvements for all clinically evaluated facial skin parameters were achieved at Week 12. Histology revealed increased stimulation of new adipocytes, epidermal keratinocyte HA (CD44), and new dermal collagen and elastin fibers post treatment.
Alastin Restorative Skin Complex Serum 2.0 with TriHex Technology has been demonstrated to be safe and effective for improving overall facial skin quality, achieving notable improvements in volume, plumping, hydration, and extracellular matrix (ECM) collagen and elastin stimulation.
含有TriHex技术的Alastin修复肌肤复合精华液（Alastin Skincare公司，加利福尼亚州卡尔斯巴德）已重新配方，添加了八肽-45和厚朴酚，以改善面部皮肤的水合作用、弹性、饱满度和整体皮肤质量。关于TriHex技术2.0和厚朴酚的详细科学研究最近已发表。本开放标签研究旨在验证相关科学，并证明该产品在中度至重度面部皮肤老化个体中的疗效和耐受性。
于2024年2月至8月进行了一项多中心临床研究。共有44名符合条件的参与者（43名女性，1名男性），年龄在35-69岁之间，Fitzpatrick皮肤类型为I-VI型，在每天两次使用含有TriHex技术的Alastin修复肌肤复合精华液2.0（RSC 2.0）并配合Alastin Skincare公司的支持性护肤方案（洁面乳、保湿霜、按需使用防晒霜）12周后，被纳入并完成了研究。仅使用支持性护肤方案进行了为期1周的导入期，并在基线时重新评估了 eligibility。在第4、8和12周进行了随访，对面部皮肤质量参数进行了临床评估，并完成了受试者评估和满意度问卷、活检采集、摄影以及水合作用和弹性测量。参与者在12周的治疗期内还记录了研究日记。
在第12周时，所有临床评估的面部皮肤参数均有显著改善。组织学显示，治疗后新脂肪细胞、表皮角质形成细胞透明质酸（CD44）以及新的真皮胶原纤维和弹性纤维的刺激增加。
含有TriHex技术的Alastin修复肌肤复合精华液2.0已被证明在改善整体面部皮肤质量方面是安全有效的，在体积、饱满度、水合作用以及细胞外基质（ECM）胶原和弹性纤维刺激方面取得了显著改善。
