Wynford-Thomas D, Stringer B M, Harach H R, Williams E D
Cell Tissue Kinet. 1985 Sep;18(5):467-73. doi: 10.1111/j.1365-2184.1985.tb00688.x.
Thyroid growth in the rat in response to a sustained elevation of serum thyrotropin (TSH) is limited by a progressive desensitization of the follicular cells to the mitogenic action of TSH which is not reversed by withdrawal of stimulation or by reduction of cell number. This study shows that, in thyroids which have reached a 'plateau' of growth, wounding induces a marked local follicular cell mitotic response which is equal in magnitude to that seen in control glands. This demonstrates that these cells, which are refractory to TSH, have not lost the capacity to divide. It is concluded that limitation of TSH-induced thyroid growth is not due to a non-specific loss of mitotic capacity resulting from severe hypothyroidism or goitrogen toxicity, or to an inherent limitation of the number of divisions which a follicular cell can undergo. The implications of these findings are discussed.
大鼠甲状腺对血清促甲状腺激素（TSH）持续升高的生长反应受到滤泡细胞对TSH促有丝分裂作用的渐进性脱敏限制，这种脱敏不会因刺激撤除或细胞数量减少而逆转。本研究表明，在已达到生长“平台期”的甲状腺中，创伤诱导显著的局部滤泡细胞有丝分裂反应，其程度与对照腺体中所见相当。这表明这些对TSH不敏感的细胞并未丧失分裂能力。得出的结论是，TSH诱导的甲状腺生长受限并非由于严重甲状腺功能减退或致甲状腺肿物质毒性导致的有丝分裂能力非特异性丧失，也不是由于滤泡细胞可经历的分裂次数存在内在限制。讨论了这些发现的意义。
