猴子妊娠实验性毒血症及肾素与醛固酮的初步报告

Abitbol M M, Ober M B, Gallo G R, Driscoll S G, Pirani C L

Am J Pathol. 1977 Mar;86(3):573-90.

Experimental toxemia of pregnancy was induced in 8 pregnant monkeys (Macacamulatta) by reducing the abdomiinal aorta to one-third of its original diameter during the last month of gestation. It was characterized by hypertension and proteinuria. In the kidney, light and electron microscopy and immunofluorescence revealed findings similar to those in human toxemia. Focal necrosis in the liver and diffuse hemorrhagic infarctions in the placenta were also observed. Plasma renin activity and aldosterone levels, as determined in blood from the uterine vein, were elevated. None of these changes were found in 4 control animals.

在8只怀孕的猕猴（恒河猴）妊娠最后一个月期间，通过将腹主动脉缩窄至其原始直径的三分之一来诱发实验性妊娠毒血症。其特征为高血压和蛋白尿。在肾脏中，光镜、电镜和免疫荧光检查显示的结果与人类毒血症相似。还观察到肝脏局灶性坏死和胎盘弥漫性出血性梗死。测定子宫静脉血中的血浆肾素活性和醛固酮水平升高。4只对照动物未发现这些变化。