Bartusis Laimonas, Krakauskaite Solventa, Kevalaite Ugne, Judickaite Austeja, Zizas Arminas, Stoskuviene Akvile, Chaleckas Edvinas, Deimantavicius Mantas, Hamarat Yasin, Scalzo Fabien, Berskiene Kristina, Januleviciene Ingrida, Ragauskas Arminas
Health Telematics Science Institute, Kaunas University of Technology, LT-51423 Kaunas, Lithuania.
Eye Clinic, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
Medicina (Kaunas). 2025 Mar 22;61(4):566. doi: 10.3390/medicina61040566.
: Normal-tension glaucoma (NTG) is a subtype of primary open-angle glaucoma characterized by progressive optic nerve damage despite intraocular pressure (IOP) remaining within the normal range. The underlying pathophysiology of NTG remains incompletely understood, and its diagnosis is often delayed due to the lack of a definitive screening tool. This study aimed to evaluate differences in intracranial pressure pulse wave amplitude recorded from closed eyelids between NTG patients and control subjects using a novel non-invasive monitoring technology. : A cross-sectional observational study was conducted, enrolling NTG patients and age-matched controls. Intracranial pressure pulse wave signals were recorded from closed eyelids using the 'Archimedes' 02 device, which employs a highly sensitive digital pressure sensor and hydromechanical coupling for signal transmission. The amplitude of recorded intracranial pressure pulse waves was analyzed and compared between groups. Statistical analyses were performed using IBM SPSS Statistics 30.0, with significance set at < 0.05. : A total of 140 participants were enrolled, including 68 NTG patients and 72 controls. After applying exclusion criteria, 63 NTG patients and 68 controls were included in the final analysis. The median intracranial pressure pulse wave amplitude was significantly higher in NTG patients (0.1326 a.u.) than in controls (0.0889 a.u.), with = 0.01. : These findings suggest that intracranial pressure pulse wave monitoring may serve as a potential biomarker for NTG. Further studies are needed to determine the diagnostic accuracy, sensitivity, and specificity of this technology for NTG detection.
正常眼压性青光眼（NTG）是原发性开角型青光眼的一种亚型，其特征是尽管眼压（IOP）保持在正常范围内，但仍会出现进行性视神经损伤。NTG的潜在病理生理学仍未完全明确，由于缺乏明确的筛查工具，其诊断往往会延迟。本研究旨在使用一种新型非侵入性监测技术，评估NTG患者与对照受试者闭眼时记录的颅内压脉搏波振幅的差异。
进行了一项横断面观察性研究，纳入NTG患者和年龄匹配的对照。使用“阿基米德”02设备从闭眼记录颅内压脉搏波信号，该设备采用高灵敏度数字压力传感器和流体力学耦合进行信号传输。分析并比较两组记录的颅内压脉搏波振幅。使用IBM SPSS Statistics 30.0进行统计分析，显著性设定为<0.05。
共纳入140名参与者，包括68例NTG患者和72名对照。应用排除标准后，最终分析纳入63例NTG患者和68名对照。NTG患者的颅内压脉搏波振幅中位数（0.1326任意单位）显著高于对照组（0.0889任意单位），P = 0.01。
这些发现表明，颅内压脉搏波监测可能作为NTG的潜在生物标志物。需要进一步研究以确定该技术对NTG检测的诊断准确性、敏感性和特异性。
