Krochmalski Marek, Kiljański Marek, Krochmalski Jakub, Grzelak Piotr, Kamecka Karolina, Mianowany Mariusz, Fabiś Jarosław
Orthopedic Surgery Department, Outpatient Orthopedic Care, Medical Magnus Clinic, 90-552 Lodz, Poland.
Polish Muscles, Ligaments and Tendons Society, 90-552 Lodz, Poland.
J Clin Med. 2025 Apr 12;14(8):2656. doi: 10.3390/jcm14082656.
In 2020, 595 million world citizens had osteoarthritis, and the largest growth in OA morbidity refers to the hip joint. Effective OA therapies have been sought for years. Assessing the treatment effectiveness and QoL improvement in hip OA after intra-articular administration of fresh peripheral blood hematopoietic CD34+ stem cells. The study comprised 49 adults (median age: 63). The SCs were injected into hip joints and straight to the bone. Hip manipulation was conducted. Patients were subjected to a standardized rehabilitation protocol. Hip degeneration was graded by Kellgren-Lawrence. Multi-factor statistical analyses, with replications, were performed. The study was an R&D project, co-financed by the E.U. Patient-reported outcomes (HOOS, SF-36) ameliorated remarkably over 24 months ( < 0.0001). Ranges of movement improved significantly ( < 0.0001). The most noticeable improvement manifested 6 months after the SC administration. Its furtherance was maintained. Intra-articular administration of CD34+ cells significantly reduces pain and improves hip joint function, regardless of the severity of OA, according to K-L, over a 24-month follow-up period. The combination of CD34+ cell therapy with joint mobilization and rehabilitation allows for the postponement of hip arthroplasty by significantly improving patients' QoL over the 24-month follow-up period.
2020年，全球有5.95亿人患骨关节炎，其中髋关节骨关节炎发病率增长最为显著。多年来一直在寻找有效的骨关节炎治疗方法。评估关节腔内注射新鲜外周血造血CD34+干细胞后髋关节骨关节炎的治疗效果和生活质量改善情况。该研究纳入了49名成年人（中位年龄：63岁）。将干细胞注射到髋关节并直达骨骼。进行了髋关节手法治疗。患者接受标准化康复方案。采用凯尔格伦-劳伦斯法对髋关节退变进行分级。进行了多次重复的多因素统计分析。该研究是一个由欧盟共同资助的研发项目。患者报告的结果（髋关节功能评分、健康调查简表）在24个月内有显著改善（<0.0001）。活动范围显著改善（<0.0001）。最明显的改善出现在干细胞给药后6个月，并持续改善。根据凯尔格伦-劳伦斯法，在24个月的随访期内，关节腔内注射CD34+细胞无论骨关节炎的严重程度如何，均能显著减轻疼痛并改善髋关节功能。CD34+细胞疗法与关节活动和康复相结合，在24个月的随访期内通过显著改善患者的生活质量，可推迟髋关节置换术。
