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跨学科护理模式下小儿肾病综合征口腔卫生及牙龈参数评估

Evaluation of oral hygiene and gingival parameters in pediatric nephrotic syndrome within an interdisciplinary care model.

作者信息

Piekoszewska-Ziętek Paula, Pańczyk-Tomaszewska Małgorzata, Olczak-Kowalczyk Dorota

机构信息

Department of Paediatric Dentistry, Medical University of Warsaw, St. Binieckiego 6, Warsaw, 02-097, Poland.

Department of Paediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.

出版信息

Sci Rep. 2025 Jul 1;15(1):21735. doi: 10.1038/s41598-025-06687-2.

DOI:10.1038/s41598-025-06687-2
PMID:40595109
Abstract

This study aimed to evaluate oral hygiene, gingival condition, and the presence of selected periodontal pathogens in children with nephrotic syndrome (NS) compared to healthy controls. The primary research question was whether interdisciplinary care contributes to better oral health in this medically compromised group.A cross-sectional study was conducted among 86 children aged 5-17 years, including 40 patients with NS and 46 healthy controls. Clinical evaluation included the Plaque Index (Pl.I.), Approximal Plaque Index (API), Gingival Index (GI), Bleeding on Probing (BoP), and presence of dental calculus. Periodontal pathogens were identified using the PET Plus microbiological test.Children with NS had better interdental hygiene and a higher proportion of individuals with good oral hygiene. Gingival inflammation indicators (GI, BoP) did not differ significantly between groups. Notably, the prevalence and bacterial load of Treponema denticola and Fusobacterium nucleatum were lower in the NS group. Dental calculus was also less frequently observed in these patients.Despite being a medically vulnerable population, children with nephrotic syndrome under interdisciplinary care demonstrated favorable oral hygiene and reduced colonization by key periodontal pathogens. These findings suggest that systematic dental follow-up integrated with nephrology care may have a protective effect on oral health and help prevent inflammation-associated complications.Implementing regular dental screening within pediatric nephrology care can enhance early intervention, reduce oral disease burden, and support systemic health in children with nephrotic syndrome.

摘要

本研究旨在评估与健康对照组相比,肾病综合征(NS)患儿的口腔卫生、牙龈状况及某些牙周病原体的存在情况。主要研究问题是跨学科护理是否有助于改善这一医学上存在健康问题的群体的口腔健康。

对86名5至17岁的儿童进行了一项横断面研究,其中包括40名NS患儿和46名健康对照。临床评估包括菌斑指数(Pl.I.)、邻面菌斑指数(API)、牙龈指数(GI)、探诊出血(BoP)以及牙结石的存在情况。使用PET Plus微生物检测法鉴定牙周病原体。

NS患儿的牙间隙卫生状况较好,口腔卫生良好的个体比例较高。两组之间的牙龈炎症指标(GI、BoP)无显著差异。值得注意的是,NS组中齿垢密螺旋体和具核梭杆菌的患病率和细菌载量较低。这些患者中牙结石的观察频率也较低。

尽管肾病综合征患儿是医学上的弱势群体,但在跨学科护理下,他们表现出良好的口腔卫生状况,关键牙周病原体的定植减少。这些发现表明,与肾病护理相结合的系统性牙科随访可能对口腔健康具有保护作用,并有助于预防炎症相关并发症。

在儿科肾病护理中实施定期牙科筛查可以加强早期干预,减轻口腔疾病负担,并支持肾病综合征患儿的全身健康。

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Evaluation of oral hygiene and gingival parameters in pediatric nephrotic syndrome within an interdisciplinary care model.跨学科护理模式下小儿肾病综合征口腔卫生及牙龈参数评估
Sci Rep. 2025 Jul 1;15(1):21735. doi: 10.1038/s41598-025-06687-2.
2
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本文引用的文献

1
Long-Term Impact of Interdisciplinary Collaboration on Oral Health in Children with Nephrotic Syndrome: A 12-Year Retrospective Study.跨学科协作对肾病综合征患儿口腔健康的长期影响:一项12年回顾性研究
J Clin Med. 2025 Apr 15;14(8):2696. doi: 10.3390/jcm14082696.
2
Dental caries, oral hygiene and salivary characteristics in children with chronic kidney disease: a case-control study.慢性肾病患儿的龋齿、口腔卫生及唾液特征:一项病例对照研究。
Pediatr Nephrol. 2025 Mar 19. doi: 10.1007/s00467-025-06730-4.
3
Gingivitis and Its Causes in Children Aged 3-7 Years.
3至7岁儿童的牙龈炎及其病因
Diagnostics (Basel). 2024 Nov 29;14(23):2690. doi: 10.3390/diagnostics14232690.
4
Oro-Dental Health and Primary Nephrotic Syndrome among Vietnamese Children.越南儿童的口腔健康与原发性肾病综合征
Children (Basel). 2021 Jun 10;8(6):494. doi: 10.3390/children8060494.
5
Selected salivary parameters in children with idiopathic nephrotic syndrome: a preliminary study.特发性肾病综合征患儿唾液参数的选择:初步研究。
BMC Oral Health. 2021 Jan 7;21(1):17. doi: 10.1186/s12903-020-01375-1.
6
Immunological Pathways Triggered by and : Therapeutic Possibilities?炎症小体激活途径及其相关治疗策略
Mediators Inflamm. 2019 Jun 24;2019:7241312. doi: 10.1155/2019/7241312. eCollection 2019.
7
Dental plaque-induced gingival conditions.牙菌斑引起的牙龈疾病。
J Periodontol. 2018 Jun;89 Suppl 1:S17-S27. doi: 10.1002/JPER.17-0095.
8
Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.系统疾病及发育和获得性状况的牙周表现:2017 年牙周病和种植体周围病分类世界研讨会第 3 工作组的共识报告。
J Periodontol. 2018 Jun;89 Suppl 1:S237-S248. doi: 10.1002/JPER.17-0733.
9
suppresses invasion of into gingival epithelial cells.抑制……侵入牙龈上皮细胞。 (原文中“into gingival epithelial cells”前缺失具体内容)
J Oral Microbiol. 2017 Jun 12;9(1):1320193. doi: 10.1080/20002297.2017.1320193. eCollection 2017.
10
Immunology of idiopathic nephrotic syndrome.特发性肾病综合征的免疫学。
Pediatr Nephrol. 2018 Apr;33(4):573-584. doi: 10.1007/s00467-017-3677-5. Epub 2017 Apr 27.