Touitou Y, Proust J, Carayon A, Klinger E, Nakache J P, Huard D, Sachet A
Clin Chim Acta. 1985 Jun 30;149(1):37-45. doi: 10.1016/0009-8981(85)90271-2.
The effects of biological (age, sex, weight) and pathological factors on plasma ferritin concentrations were documented in 776 unselected elderly patients aged 80.9 +/- 9.7 yr. A marked shift towards high values (159 +/- 142 micrograms/l) was observed in this elderly population together with the persistence of the well-known sex-related difference in ferritin levels (higher levels in men). Twenty-five percent of the population had high levels of ferritin (greater than or equal to 220 micrograms/l) but 75% of these high values (i.e. 18.5% of the population) could be readily explained by their known association with a particular pathology (inflammatory syndrome, renal failure, cardiovascular diseases, alcoholism). Only 6% of the population had unexplained high ferritin concentrations. Therefore, our data strongly suggest that the repeatedly reported increase of ferritin in the aged population is merely related to an age-associated pathology and may not be a normal physiological event occurring during the process of aging.
在776名年龄为80.9±9.7岁、未经挑选的老年患者中，记录了生物学因素（年龄、性别、体重）和病理因素对血浆铁蛋白浓度的影响。在这一老年人群中，观察到血浆铁蛋白浓度显著向高值偏移（159±142微克/升），同时铁蛋白水平中众所周知的性别差异依然存在（男性水平更高）。25%的人群铁蛋白水平较高（≥220微克/升），但其中75%的高值（即占人群的18.5%）可通过其与特定病理情况（炎症综合征、肾衰竭、心血管疾病、酗酒）的已知关联得到合理解释。只有6%的人群铁蛋白浓度升高无法解释。因此，我们的数据强烈表明，在老年人群中反复报道的铁蛋白升高仅仅与年龄相关的病理情况有关，可能并非衰老过程中发生的正常生理事件。
