Eira Ana, Gonçalves Maria Beatriz S, Fongang Yannick Stéphane Fotsing, Domingues Cátia, Jarak Ivana, Mascarenhas-Melo Filipa, Figueiras Ana
Laboratory of Drug Development and Technologies, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.
Higher Teachers' Training College, The University of Maroua, Maroua P.O. Box 55, Cameroon.
Pharmaceutics. 2025 Mar 26;17(4):422. doi: 10.3390/pharmaceutics17040422.
(), commonly known as the "Lingzhi" or "Reishi" mushroom, has long been recognized for its potential health benefits and medicinal properties in traditional Chinese medicine. The unique potential combination of bioactive compounds present in , such as triterpenoids, polysaccharides, and peptides, has inspired interest in leveraging their therapeutic potential In recent years, the emerging field of nanotechnology has opened up new possibilities for using the remarkable properties of at the nanoscale. The main objective of this review is to explore the unique potential of in traditional and innovative therapies, particularly in cancer treatment, and to assess how nanotechnology-based strategies can enhance its therapeutic applications.is to explore. Nanotechnology-based strategies have been investigated for the efficient extraction and purification of bioactive compounds from . Additionally, nanocarriers and nanoformulations have been developed to protect these sensitive bioactive compounds from degradation, ensuring their stability during storage and transportation. The use of -based nanomaterials has shown promising results in several biomedical applications, namely due to their anticancer activity by targeting cancer cells, inducing apoptosis, and inhibiting tumor growth. The combination of and nanotechnology presents an exciting frontier in the development of novel therapeutic and biomedical applications. Nevertheless, further research and development in this interdisciplinary field are warranted to fully exploit the synergistic benefits offered by and nanotechnology. Future prospects include the development of robust clinical trials focused on nanotechnology-based cancer therapies to clarify mechanisms of actions and optimize formulations, ultimately leading to innovative solutions for human health and well-being.
(),通常被称为“灵芝”,长期以来在中国传统医学中因其潜在的健康益处和药用特性而受到认可。()中存在的生物活性化合物,如三萜类化合物、多糖和肽,其独特的潜在组合激发了人们利用其治疗潜力的兴趣。近年来,新兴的纳米技术领域为利用()在纳米尺度上的卓越特性开辟了新的可能性。本综述的主要目的是探索()在传统和创新疗法中的独特潜力,特别是在癌症治疗方面,并评估基于纳米技术的策略如何增强其治疗应用。基于纳米技术的策略已被研究用于从()中高效提取和纯化生物活性化合物。此外,还开发了纳米载体和纳米制剂来保护这些敏感的生物活性化合物不被降解,确保它们在储存和运输过程中的稳定性。基于()的纳米材料在几种生物医学应用中已显示出有前景的结果,特别是由于它们通过靶向癌细胞、诱导细胞凋亡和抑制肿瘤生长而具有抗癌活性。()与纳米技术的结合在新型治疗和生物医学应用的开发中呈现出一个令人兴奋的前沿领域。然而,在这个跨学科领域需要进一步的研究和开发,以充分利用()和纳米技术提供的协同效益。未来的前景包括开展专注于基于()纳米技术的癌症治疗的强大临床试验,以阐明作用机制并优化制剂,最终为人类健康和福祉带来创新解决方案。