Can Ayça, Kızılbey Kadriye
Biomedical Engineering Department, Graduate School of Natural and Applied Sciences, Acıbadem University, İstanbul 34752, Türkiye.
Department of Natural Sciences, Faculty of Engineering and Natural Sciences, Acıbadem University, İstanbul 34752, Türkiye.
Gels. 2024 Sep 4;10(9):576. doi: 10.3390/gels10090576.
Metallic nanoparticles are of growing interest due to their broad applications. This study presents the green synthesis of zinc oxide (ZnO) nanoparticles (ZnNPs) using mushroom extract, characterized by DLS, SEM, XRD, and FTIR spectroscopy analyses. The synthesis parameters, including extract/salt ratio and mixing time, significantly influenced nanoparticle yield, size, and polydispersity, with longer mixing times leading to larger, more varied particles. Specifically, the sizes of ZnNPs synthesized at a 1:1 extract/ZnCl ratio after 3 h and 24 h were 90.0 nm and 243.3 nm, with PDI values of 48.69% and 51.91%, respectively. At a 1:2 ratio, the sizes were 242.3 nm at 3 h (PDI: 43.19%) and a mixture of 1.5 nm, 117.4 nm, and 647.9 nm at 24 h (PDI: 2.72%, 10.97%, and 12.43%). Polymer films incorporating PVA, chitosan, and ZnNPs were analyzed for their morphological, spectroscopic, and mechanical properties. Chitosan reduced tensile strength and elongation due to its brittleness, while ZnNPs further increased film brittleness and structural degradation. A comparison of the tensile strength of films A and C revealed that the addition of chitosan to the PVA film resulted in an approximately 10.71% decrease in tensile strength. Similarly, the analysis of films B1 and B2 showed that the tensile strength of the B2 film decreased by 10.53%. Swelling tests showed that ZnNPs initially enhanced swelling, but excessive amounts led to reduced capacity due to aggregation. This pioneering study demonstrates the potential of extract in nanoparticle synthesis and provides foundational insights for future research, especially in wound dressing applications.
由于其广泛的应用，金属纳米颗粒越来越受到关注。本研究介绍了使用蘑菇提取物绿色合成氧化锌（ZnO）纳米颗粒（ZnNPs），并通过动态光散射（DLS）、扫描电子显微镜（SEM）、X射线衍射（XRD）和傅里叶变换红外光谱（FTIR）分析对其进行表征。合成参数，包括提取物/盐的比例和混合时间，对纳米颗粒的产量、尺寸和多分散性有显著影响，混合时间越长，颗粒越大且越多样。具体而言，在1:1提取物/ZnCl比例下合成3小时和24小时后的ZnNPs尺寸分别为90.0纳米和243.3纳米，多分散指数（PDI）值分别为48.69%和51.91%。在1:2比例下，3小时时尺寸为242.3纳米（PDI：43.19%），24小时时为1.5纳米、117.4纳米和647.9纳米的混合物（PDI：2.72%、10.97%和12.43%）。对含有聚乙烯醇（PVA）、壳聚糖和ZnNPs的聚合物薄膜的形态、光谱和力学性能进行了分析。壳聚糖因其脆性降低了拉伸强度和伸长率，而ZnNPs进一步增加了薄膜的脆性和结构降解。对薄膜A和C的拉伸强度比较表明，在PVA薄膜中添加壳聚糖导致拉伸强度下降约10.71%。同样，对薄膜B1和B2的分析表明，B2薄膜的拉伸强度下降了10.53%。溶胀试验表明，ZnNPs最初增强了溶胀，但过量会由于聚集导致溶胀能力降低。这项开创性研究证明了提取物在纳米颗粒合成中的潜力，并为未来研究提供了基础见解，特别是在伤口敷料应用方面。
