CAS Key Laboratory of High Magnetic Field and Iron Beam Physical Biology, Institute of Intelligent Agriculture, Institute of Intelligent Machines, Hefei Institute of Physical Sciences, Chinese Academy of Sciences, Hefei, 230031, China.
Science Island Branch of Graduate School, University of Science and Technology of China, Hefei, 230026, China.
Food Funct. 2023 Feb 21;14(4):1812-1838. doi: 10.1039/d2fo01683d.
With a long history in traditional Asian medicine, () is a mushroom species suggested to improve health and extend life. Its medicinal reputation has merited it with numerous attributes and titles, and it is evidenced to be effective in the prevention and treatment of various metabolic disorders owing to its unique source of bioactive metabolites, primarily polysaccharides, triterpenoids, and polyphenols, attributed with antioxidant, anti-inflammatory, anticancer, hepatoprotective, antidiabetic activities, . These unique potential pharmaceutical properties have led to its demand as an important resource of nutrient supplements in the food industry. It is reported that the variety of therapeutic/pharmacological properties was mainly due to its extensive prebiotic and immunomodulatory functions. All literature summarized in this study was collated based on a systematic review of electronic libraries (PubMed, Scopus databases, Web of Science Core Collection, and Google Scholar) from 2010-2022. This review presents an updated and comprehensive summary of the studies on the immunomodulatory therapies and nutritional significance of , with the focus on recent advances in defining its immunobiological mechanisms and the possible applications in the food and pharmaceutical industries for the prevention and management of chronic diseases. In addition, toxicological evidence and the adoption of standard pharmaceutical methods for the safety assessment, quality assurance, and efficacy testing of -derived compounds will be the gateway to bringing them into health establishments.
在传统亚洲医学中有着悠久历史的灵芝被认为是一种可以改善健康和延长寿命的蘑菇品种。由于其独特的生物活性代谢产物来源，主要是多糖、三萜类和多酚类，具有抗氧化、抗炎、抗癌、保肝、降血糖等活性，灵芝被赋予了许多特性和称号，其在预防和治疗各种代谢紊乱方面的功效也得到了证实。这些独特的潜在药物特性使其成为食品工业中营养补充剂的重要资源。据报道，灵芝的治疗/药理学特性主要是由于其广泛的益生元和免疫调节功能。本研究综述的所有文献均基于 2010 年至 2022 年对电子图书馆（PubMed、Scopus 数据库、Web of Science 核心合集和 Google Scholar）的系统综述进行整理。本综述对灵芝的免疫调节疗法和营养意义进行了更新和全面的总结，重点介绍了其免疫生物学机制的最新进展以及在食品和制药行业中预防和管理慢性疾病的可能应用。此外，灵芝衍生化合物的毒理学证据和采用标准药物方法进行安全性评估、质量保证和功效测试将是将其引入医疗机构的途径。
