Department of adult health nursing, school of nursing, college of health science, Aksum university, Axum, Tigray, Ethiopia.
Department of adult health nursing, school of nursing, college of health science, Aksum university, Axum, Tigray, Ethiopia.
J Infect Public Health. 2024 Oct;17(10):102533. doi: 10.1016/j.jiph.2024.102533. Epub 2024 Aug 29.
The COVID-19 pandemic has caused 14.83 million deaths globally. This systematic review and meta-analysis aimed to provide a pooled estimate of the overall mortality and morbidity of critically ill COVID-19 patients.
Four electronic databases, Medline/PubMed, the Cochrane Library, the WHO COVID-19 database, and the Web of Science, were used to identify relevant studies. Two authors independently screened the studies, evaluated the eligibility criteria and resolved discrepancies through discussion with the third author. The pooled effect size was computed using STATA software version 14. The Cochran Q test and I test were utilized to assess heterogeneity across the studies. Additionally, subgroup analysis, sensitivity analysis, and publication bias were evaluated. It is registered in Prospero with Prospero ID CRD42020212146.
A total of 1003 published articles were screened from various databases, and 24 studies involving a total of 142,291 critically ill COVID-19 participants were selected for inclusion in the review. Among the participants, 67 % were male, and the mean age was 63.43 + SD3.33 years. The mortality rate reported in the individual studies ranged from 4.5 % to 69.5 %. The findings from the analysis revealed that the overall pooled mortality rate was 34 % (95 % confidence interval: 31 %-37 %). Additionally, the findings showed that 62 % of critically ill COVID-19 patients required mechanical ventilation, while 68.7 % of these patients had chronic disease comorbidities.
Critically ill COVID-19 patients face a high-risk risk of death, with an estimate of about one in three patients dying from the virus. Notably, a substantial portion of critically ill COVID-19 patients (62 %) require mechanical ventilation; surprisingly, more than two-thirds of patients with COVID-19 have chronic disease comorbidities, highlighting the importance of managing comorbidities in this population.
COVID-19 大流行已在全球造成 1483 万人死亡。本系统评价和荟萃分析旨在提供 COVID-19 危重症患者总体死亡率和发病率的汇总估计。
使用四个电子数据库，即 Medline/PubMed、Cochrane 图书馆、世界卫生组织 COVID-19 数据库和 Web of Science，来识别相关研究。两位作者独立筛选研究，评估纳入标准，并通过与第三位作者讨论解决分歧。使用 STATA 软件版本 14 计算汇总效应量。使用 Cochran Q 检验和 I 检验评估研究之间的异质性。此外，还进行了亚组分析、敏感性分析和发表偏倚评估。它在 Prospero 中注册，注册号为 Prospero ID CRD42020212146。
从各个数据库筛选出 1003 篇已发表的文章，共纳入 24 项研究，共纳入 142291 例 COVID-19 危重症患者。参与者中 67%为男性，平均年龄为 63.43 ± 3.33 岁。个别研究报告的死亡率范围为 4.5%至 69.5%。分析结果显示，总体汇总死亡率为 34%（95%置信区间：31%-37%）。此外，研究结果表明，62%的 COVID-19 危重症患者需要机械通气，而这些患者中有 68.7%患有慢性疾病合并症。
COVID-19 危重症患者面临较高的死亡风险，估计约有三分之一的患者死于该病毒。值得注意的是，相当一部分 COVID-19 危重症患者（62%）需要机械通气；令人惊讶的是，超过三分之二的 COVID-19 患者患有慢性疾病合并症，这突显了在该人群中管理合并症的重要性。
