Zhou Renjun, Weng Shaoping, He Jianguo
State Key Laboratory of Biocontrol/School of Marine Sciences, Sun Yat-sen University, Guangzhou 510275, China.
School of Life Sciences/Southern Marine Sciences and Engineering Guangdong Laboratory (Zhuhai)/China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Sun Yat-sen University, Guangzhou 510275, China.
Microorganisms. 2025 Apr 10;13(4):864. doi: 10.3390/microorganisms13040864.
Pathogenic infections can reshape the intestinal microbiota of aquatic animals, thereby impacting their health status. In this study, we aimed to investigate whether infection induces dysbiosis in the intestinal bacterial community of and to assess the associated ecological risks. Our findings revealed the deterministic processes in intestinal bacterial community assembly during bacterial infections, indicating that host selection, i.e., host immune response post-infection, has a significant influence on intestinal microbes. More importantly, we found that bacterial infection reshaped the intestinal community by reducing the relative abundance of probiotic species (e.g., , , , , , ) and increasing the relative abundance of species (, , , and ). Significant negative correlations were observed between the relative abundance of these species and the relative abundance of species. Moreover, the control contained a substantially higher number of keystone species belonging to in the bacterial community network, whereas bacterial infection individuals had few or no keystone species belonging to , with keystone species belonging to becoming more prominent. Thus, the significant increase in species abundance in the intestine following bacterial infection was associated with the marked reduction in species. Our findings will provide valuable insights into the complex interactions among bacterial infection, intestinal microbiota, and host health, and they provide guidance for the development of probiotics in promoting the healthy culture of .
致病性感染可重塑水生动物的肠道微生物群，从而影响其健康状况。在本研究中，我们旨在调查感染是否会导致[具体水生动物名称]肠道细菌群落失调，并评估相关的生态风险。我们的研究结果揭示了细菌感染期间肠道细菌群落组装中的确定性过程，表明宿主选择，即感染后的宿主免疫反应，对肠道微生物有重大影响。更重要的是，我们发现细菌感染通过降低益生菌[具体益生菌种类名称]（如[列举具体种类]）的相对丰度和增加[具体有害菌种类名称]（[列举具体种类]）的相对丰度来重塑肠道群落。观察到这些[有害菌种类名称]的相对丰度与[益生菌种类名称]的相对丰度之间存在显著负相关。此外，对照[具体水生动物名称]在细菌群落网络中包含大量属于[具体有益菌属名称]的关键物种，而细菌感染个体几乎没有或没有属于[具体有益菌属名称]的关键物种，属于[具体有害菌属名称]的关键物种变得更加突出。因此，细菌感染后[具体水生动物名称]肠道中[有害菌种类名称]丰度的显著增加与[益生菌种类名称]的显著减少有关。我们的研究结果将为细菌感染、肠道微生物群和宿主健康之间的复杂相互作用提供有价值的见解，并为开发促进[具体水生动物名称]健康养殖的益生菌提供指导。
