Kristensen S, Vorre P, Elbrønd O, Søgaard H
Clin Otolaryngol Allied Sci. 1985 Jun;10(3):125-34. doi: 10.1111/j.1365-2273.1985.tb01181.x.
Nasal Schneiderian papillomas are unique lesions involving the mucosa of the nasal cavity and paranasal sinuses. Most often epidermoid in histological appearance, they favour 2 sites: the septum and the lateral wall of the nasal cavity. The medical literature on these tumours contains a plethora of contradictions concerning the nomenclature and no less than 54 separate designations are used. The synonyms are discussed and the term Schneiderian papilloma is proposed as the most suitable alternative. This study includes 83 patients with Schneiderian papillomas in whom the history, clinical and radiological findings, treatment procedures, pathological sections, recurrences, and associated malignancies were analyzed. Histological and clinical features were not helpful in predicting recurrence, but the recurrence rate was related to the treatment modalities; with 17% recurrences using an extranasal approach (lateral rhinotomy) and 59% using intranasal approach with limited excision. Schneiderian papillomas were associated with squamous cell carcinoma in 7 patients. Simultaneous papilloma and carcinoma were demonstrated in 4 patients at presentation (5%) and subsequently developing carcinoma in 3 patients (4%). As recurrences are frequent after inadequate removal and as association with maligancies may occur in both septal and lateral wall papillomas, radical aggressive surgery, thorough histological examination of the entire specimen, and careful follow-up are advocated.
鼻内翻性乳头状瘤是一种累及鼻腔和鼻窦黏膜的独特病变。其组织学表现多为表皮样，好发于两个部位：鼻中隔和鼻腔外侧壁。关于这些肿瘤的医学文献在命名方面存在大量矛盾之处，使用的名称多达54种。本文讨论了同义词，并提出“内翻性乳头状瘤”这一术语作为最合适的选择。本研究纳入了83例内翻性乳头状瘤患者，分析了他们的病史、临床及影像学表现、治疗方法、病理切片、复发情况以及相关的恶性肿瘤。组织学和临床特征无助于预测复发，但复发率与治疗方式有关；鼻外入路（外侧鼻切开术）的复发率为17%，鼻内入路有限切除的复发率为59%。7例内翻性乳头状瘤患者合并鳞状细胞癌。4例患者（5%）在初诊时同时发现乳头状瘤和癌，3例患者（4%）随后发生癌变。由于切除不彻底时复发频繁，且鼻中隔和鼻腔外侧壁乳头状瘤均可能合并恶性肿瘤，因此提倡进行根治性积极手术、对整个标本进行全面的组织学检查以及仔细的随访。
