Stange T, Schultz-Coulon H-J
Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, plastische Operationen, Phoniatrie und Pädaudiologie, Städtische Kliniken Neuss, Lukaskrankenhaus GmbH, Preussenstrasse 84, 41456, Neuss.
HNO. 2008 Jun;56(6):614-22. doi: 10.1007/s00106-007-1607-8.
Inverted papillomas require radical resection because of their high recurrence rate and expansive growth and the risk of malignant degeneration. Since the late 1980s surgical resection has been performed predominantly as an endoscopy-/microscopy-aided procedure through an endonasal approach. The extranasal approach is only used in the case of papillomas in unusual locations or ones that have expanded to an exceptional degree. The goal of the present study was a comparative evaluation of the results of this relatively new treatment strategy and of external sinus surgery in our own patients, with particular reference to the recurrence rate.
Since 1989 a total of 80 patients have undergone surgery for inverted papilloma and have been followed up at regular intervals by means of endoscopic examinations. In any patients with a recurrence the revision operation was carried out through an extranasal approach when the papilloma was in the anterior or laterocaudal maxillary sinus or in the frontal sinus; in all other cases an endonasal approach was used for the revision surgery. The mean period of follow-up was 43 months (range 15 months to 16years).
In most patients (n=64, 80%) the endonasal surgical approach was used for the primary surgical treatment, while in 16 patients (20%) an extranasal approach was used initially. In 2 patients (2.6%) a squamous cell carcinoma was discovered adjacent to the papilloma. These two therapeutic special cases were not considered evaluable in the analysis of recurrences. Recurrences were seen in 14 patients (17.9%, n=78), in 11 patients after endonasal surgery (17.5%, n=11) and in 3 (20%, n=15) after extranasal resection. The majority of recurrences developed in patients with T3 papillomas.
The recurrence rates observed after endonasal resection are comparable to those after extranasal surgery. Thus, a primary endonasal approach does not mean any prognostic disadvantage. This approach should therefore be given preference over extranasal approaches whenever possible, because there are fewer side-effects and recovery is faster than after extranasal surgery.
内翻性乳头状瘤因其高复发率、浸润性生长及恶变风险,需要进行根治性切除。自20世纪80年代末以来,手术切除主要通过鼻内镜/显微镜辅助经鼻内入路进行。鼻外入路仅用于肿瘤位于特殊位置或扩展程度异常的乳头状瘤病例。本研究的目的是比较评估这种相对较新的治疗策略与我们自己患者的鼻窦外手术结果,特别是复发率。
自1989年以来,共有80例患者接受了内翻性乳头状瘤手术,并定期通过内镜检查进行随访。对于任何复发患者,当乳头状瘤位于上颌窦前壁或后外侧壁或额窦时,通过鼻外入路进行翻修手术;在所有其他情况下,翻修手术采用鼻内入路。平均随访时间为43个月(范围为15个月至16年)。
大多数患者(n = 64,80%)初次手术采用鼻内手术入路,而16例患者(20%)最初采用鼻外入路。在2例患者(2.6%)中,在乳头状瘤旁发现了鳞状细胞癌。在复发分析中,这两个特殊治疗病例不被视为可评估病例。14例患者(17.9%,n = 78)出现复发,其中11例在鼻内手术后复发(17.5%,n = 11),3例(20%,n = 15)在鼻外切除后复发。大多数复发发生在T3期乳头状瘤患者中。
鼻内切除术后观察到的复发率与鼻外手术相当。因此,初次鼻内入路并不意味着任何预后劣势。因此,只要可能,应优先选择这种方法而非鼻外入路,因为其副作用较少,恢复比鼻外手术后更快。