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肉桂醛在体外抑制猪繁殖与呼吸综合征病毒2型的复制。

Cinnamaldehyde Inhibits the Replication of Porcine Reproductive and Respiratory Syndrome Virus Type 2 In Vitro.

作者信息

Song Junzhu, Zhang Jingyu, Chen Jian, Chen Songbiao, Yu Zuhua, He Lei, Ding Ke, Wei Ying

机构信息

Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China.

Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Luoyang 471003, China.

出版信息

Viruses. 2025 Mar 31;17(4):506. doi: 10.3390/v17040506.

DOI:10.3390/v17040506
PMID:40284949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12031439/
Abstract

Globally, the swine industry suffers significant economic losses due to the presence of porcine reproductive and respiratory syndrome virus (PRRSV). Unfortunately, existing vaccines fail to offer adequate protection against the various strains of PRRSV, and there are currently no specific treatments available for this virus. In this study, we screened four natural products and identified cinnamaldehyde (CA) as an effective inhibitor of PRRSV infection in Marc-145 cells. CA could achieve an inhibition rate of up to 93% on PRRSV N protein at 160 μM. Mechanistically, CA exerted anti-PRRSV ability in different treatment modes. CA could directly interact with PRRSV particles. Cinnamaldehyde blocks the binding, entry, replication, and release of PRRSV. Furthermore, a significant reduction in dsRNA levels was observed in the CA-treated groups compared to the control groups. In conclusion, our research demonstrated that CA could inhibit essential stages of the PRRSV lifecycle: binding, entry, replication, and release. CA could directly interact with PRRSV. Additionally, CA disrupted the expression of dsRNA during viral replication, thereby suppressing in vitro PRRSV replication in Marc-145 cells. This study provides crucial perspectives on the potential application of CA for the prevention and treatment of PRRS.

摘要

在全球范围内，猪产业因猪繁殖与呼吸综合征病毒（PRRSV）的存在而遭受重大经济损失。不幸的是，现有的疫苗无法为各种PRRSV毒株提供充分的保护，并且目前针对这种病毒没有特效治疗方法。在本研究中，我们筛选了四种天然产物，并确定肉桂醛（CA）是Marc-145细胞中PRRSV感染的有效抑制剂。在160μM时，CA对PRRSV N蛋白的抑制率可达93%。从机制上讲，CA在不同的处理模式下发挥抗PRRSV能力。CA可直接与PRRSV颗粒相互作用。肉桂醛阻断PRRSV的结合、进入、复制和释放。此外，与对照组相比，在CA处理组中观察到dsRNA水平显著降低。总之，我们的研究表明，CA可抑制PRRSV生命周期的关键阶段：结合、进入、复制和释放。CA可直接与PRRSV相互作用。此外，CA在病毒复制过程中破坏了dsRNA的表达，从而抑制了Marc-145细胞中PRRSV的体外复制。本研究为CA在PRRS预防和治疗中的潜在应用提供了关键视角。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a784/12031439/434fbee84470/viruses-17-00506-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a784/12031439/d192d118268d/viruses-17-00506-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a784/12031439/7bd7b4e20c5d/viruses-17-00506-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a784/12031439/6d6f7bf5d224/viruses-17-00506-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a784/12031439/ea1c21c05aea/viruses-17-00506-g003.jpg
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本文引用的文献

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Microbiol Spectr. 2024 Mar 5;12(3):e0347923. doi: 10.1128/spectrum.03479-23. Epub 2024 Feb 1.
2
Bergamottin Inhibits PRRSV Replication by Blocking Viral Non-Structural Proteins Expression and Viral RNA Synthesis.佛手柑素通过抑制病毒非结构蛋白表达和病毒 RNA 合成来抑制 PRRSV 复制。
Viruses. 2023 Jun 13;15(6):1367. doi: 10.3390/v15061367.
3
Anti-Inflammatory Effect of Cinnamaldehyde in a Mouse Model of 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis.
肉桂醛在2,4-二硝基氟苯诱导的特应性皮炎小鼠模型中的抗炎作用
Indian J Dermatol. 2023 Mar-Apr;68(2):170-177. doi: 10.4103/ijd.ijd_576_22.
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Antioxidant and Anti-Inflammatory Effect of Cinnamon ( J. Presl) Bark Extract after In Vitro Digestion Simulation.肉桂（J. Presl）树皮提取物体外消化模拟后的抗氧化和抗炎作用
Foods. 2023 Jan 18;12(3):452. doi: 10.3390/foods12030452.
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Chem Biodivers. 2023 Feb;20(2):e202200089. doi: 10.1002/cbdv.202200089. Epub 2023 Jan 27.
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