Myers J B, Smidt V J, Doig S, Di Nicolantonio R, Morgan T O
Clin Exp Pharmacol Physiol. 1985 May-Jun;12(3):217-20. doi: 10.1111/j.1440-1681.1985.tb02634.x.
Blood pressure, sodium excretion and salt taste were examined in Sprague Dawley (SD) and Munich Wistar (MW) rats exposed prenatally to either a high salt (2.3% NaCl w/w) or control diet. There was no significant difference in blood pressure at 2, 6 or 12 months between high salt and control groups in either strain. Similarly there was no significant difference in sodium excretion following a saline load by gavage (150 mmol/l, 1.5% BW). Munich Wistar rats which received high salt diet prenatally exhibited a reduced saline preference when offered a choice between water and 150 mmol/l NaCl as drinking fluid. There was no significant difference in saline preference between Sprague Dawley rats which received the high salt or control diet. Prenatal exposure to high salt diet failed to alter the blood pressure or excretion of a salt load in either SD or MW rats. In MW rats but not SD high salt diet prenatally resulted in a reduced saline preference at 3 months of age.
对产前暴露于高盐（2.3% NaCl w/w）或对照饮食的斯普拉格-道利（SD）大鼠和慕尼黑威斯塔（MW）大鼠进行了血压、钠排泄和盐味觉检测。在这两种品系中，高盐组和对照组在2个月、6个月或12个月时的血压均无显著差异。同样，通过灌胃给予生理盐水负荷（150 mmol/l，1.5%体重）后，钠排泄也无显著差异。产前接受高盐饮食的慕尼黑威斯塔大鼠在提供水和150 mmol/l NaCl作为饮用水选择时，表现出对盐水的偏好降低。接受高盐或对照饮食的斯普拉格-道利大鼠在盐水偏好上没有显著差异。产前暴露于高盐饮食未能改变SD或MW大鼠的血压或盐负荷排泄。在MW大鼠而非SD大鼠中，产前高盐饮食导致3月龄时对盐水的偏好降低。
