Effect of the Chilean Bean Landrace Peumo on Metabolic Syndrome-Related Parameters in C57BL/6 Mice Fed With a High-Fat Diet.

SCOPE

We report a nutritional intervention involving supplementation with boiled beans and secondary metabolites-enriched extracts (SMEEs) from a Chilean Phaseolus vulgaris landrace in mice with induced metabolic syndrome (MS).

METHODS AND RESULTS

The effects of supplementation were assessed in C57BL6 mice with MS induced by a high-fat diet. Boiled beans (75 and 150 mg animal day) and the SMEE (0.8 and 8 mg animal day) were administered daily for 4 months. Weight and glycemia were measured weekly. At the end of the experiment, glycemia, total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, triglycerides, protein carbonyls, and carboxymethyl lysine (CML) levels were determined in plasma. Oral intake of the SMEE decreased glycemia at the end of the intervention. No statistically significant difference in glycemia was found for the boiled beans compared with controls. The SMEE at 0.8 mg animal day decreased the total amount of CML, mainly in proteins with molecular masses >75 kDa, in agreement with the results for carbonylated proteins.

CONCLUSION

The SMEE of Peumo beans reduces glycemia at the end of the intervention and decreases total CML in plasma, suggesting a potential beneficial effect of bean intake. The results obtained in the intervention encourage further studies in Chilean bean landraces.