Schramm Stefan, Lippold Tim, Navizet Isabelle
Applied Organic Chemistry, University of Applied Sciences Dresden, Friedrich-List-Platz 1, 01069 Dresden, Germany.
Institute of Organic Chemistry, Department of Chemistry, University of Cologne, Greinstr. 4, 50939 Cologne, Germany.
Molecules. 2025 Mar 25;30(7):1459. doi: 10.3390/molecules30071459.
Recently, 2-Coumaranones have emerged as a highly promising class of chemiluminescent compounds, distinguished by their unique structural properties that facilitate efficient light emission. This review provides a comprehensive analysis of their synthesis, structural characteristics, and chemiluminescence mechanisms, integrating historical perspectives with the latest advancements in the field. Beyond their intrinsic photophysical and chemical properties, 2-coumaranones have demonstrated broad utility across bioanalytical and material sciences. Notable applications include enzyme-catalyzed chemiluminescence in aqueous systems, glucose and urease-triggered detection assays, and mechano-base-responsive luminescence for stress sensing. Additionally, recent developments in chemiluminescent protective groups and their incorporation into advanced functional materials underscore the versatility of these compounds. Despite significant progress, key challenges remain, particularly in optimizing quantum yield, emission properties, and solvent compatibility for practical applications. Future research should prioritize the development of highly tunable 2-coumaranone derivatives with enhanced spectral and kinetic properties, further expanding their potential in diagnostics, bioimaging, and mechanoluminescent sensing. By addressing these challenges, 2-coumaranones could pave the way for next-generation chemiluminescent technologies with unprecedented sensitivity and adaptability.
最近，2-香豆满酮已成为一类极具前景的化学发光化合物，其独特的结构特性有助于高效发光。本综述对其合成、结构特征和化学发光机制进行了全面分析，将历史观点与该领域的最新进展相结合。除了其固有的光物理和化学性质外，2-香豆满酮在生物分析和材料科学领域已展现出广泛的用途。显著的应用包括水体系中的酶催化化学发光、葡萄糖和脲酶触发的检测分析以及用于应力传感的机械碱响应发光。此外，化学发光保护基团的最新进展及其在先进功能材料中的应用突出了这些化合物的多功能性。尽管取得了重大进展，但关键挑战仍然存在，特别是在优化量子产率、发射特性和实际应用中的溶剂兼容性方面。未来的研究应优先开发具有增强光谱和动力学性质的高度可调谐2-香豆满酮衍生物，进一步扩大其在诊断、生物成像和机械发光传感方面的潜力。通过应对这些挑战，2-香豆满酮可为具有前所未有的灵敏度和适应性的下一代化学发光技术铺平道路。
